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Image Unavailable-BOSSBS-0675R-A488

Anti-FGFR2 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-0675R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-0675R-A488
Codice articolo locale: BOSSBS-0675R-A488
Descrizione: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0675R-CY7

Anti-FGFR2 Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-0675R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-0675R-CY7
Codice articolo locale: BOSSBS-0675R-CY7
Descrizione: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4897R-CY3

Anti-ACKR3 Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-4897R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-4897R-CY3
Codice articolo locale: BOSSBS-4897R-CY3
Descrizione: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4897R-CY5.5

Anti-ACKR3 Rabbit Polyclonal Antibody (Cy5.5®)

Codice catalogo: (BOSSBS-4897R-CY5.5)
Fornitore: Bioss
Codice articolo fornitore: BS-4897R-CY5.5
Codice articolo locale: BOSSBS-4897R-CY5.5
Descrizione: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
UOM: 1 * 100 µl
Product Image-PRSI26-430

Anti-RTN1 Rabbit Polyclonal Antibody

Codice catalogo: (PRSI26-430)
Fornitore: ProSci Inc.
Codice articolo fornitore: 26-430
Codice articolo locale: PRSI26-430
Descrizione: Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity.
UOM: 1 * 50 µG
Product Image-PRSI26-429

Anti-RTN1 Rabbit Polyclonal Antibody

Codice catalogo: (PRSI26-429)
Fornitore: ProSci Inc.
Codice articolo fornitore: 26-429
Codice articolo locale: PRSI26-429
Descrizione: Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells.This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity.
UOM: 1 * 50 µG
Image Unavailable-BOSSBS-4897R-A680

Anti-CXCR7/RDC1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-4897R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-4897R-A680
Codice articolo locale: BOSSBS-4897R-A680
Descrizione: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.
UOM: 1 * 100 µl
Product Image-PRSI25-921

Anti-SLC9A7 Rabbit Polyclonal Antibody

Codice catalogo: (PRSI25-921)
Fornitore: ProSci Inc.
Codice articolo fornitore: 25-921
Codice articolo locale: PRSI25-921
Descrizione: Organelles of the secretory and endocytic pathways are distinguished by their luminal acidity, which is generated by the activity of an electrogenic vacuolar-type hydrogen ATPase. Progressive acidification of vesicles in the endocytic pathway is essential for the redistribution and degradation of internalized membrane proteins, such as ligand receptor complexes and fluid-phase solutes. It may play an important role in maintaining cation homeostasis and function of the trans-Golgi network.Organelles of the secretory and endocytic pathways are distinguished by their luminal acidity, which is generated by the activity of an electrogenic vacuolar-type hydrogen ATPase. Progressive acidification of vesicles in the endocytic pathway is essential for the redistribution and degradation of internalized membrane proteins, such as ligand receptor complexes and fluid-phase solutes. This gene is expressed predominantly in the trans-Golgi network, and mediates the influx of sodium or potassium in exchange for hydrogen. It may thus play an important role in maintaining cation homeostasis and function of the trans-Golgi network. This gene is part of a gene cluster on chromosome Xp11.23.Organelles of the secretory and endocytic pathways are distinguished by their luminal acidity, which is generated by the activity of an electrogenic vacuolar-type hydrogen ATPase. Progressive acidification of vesicles in the endocytic pathway is essential for the redistribution and degradation of internalized membrane proteins, such as ligand receptor complexes and fluid-phase solutes. This gene is expressed predominantly in the trans-Golgi network, and mediates the influx of sodium or potassium in exchange for hydrogen. It may thus play an important role in maintaining cation homeostasis and function of the trans-Golgi network. This gene is part of a gene cluster on chromosome Xp11.23.
UOM: 1 * 50 µG
Product Image-113-1662

Tute, Mutex2

Fornitore: Honeywell Safety
Descrizione: Le proprietà antistatiche interne ed esterne consentono al capo di abbigliamento di essere indossato persino per attività soggette a requisiti molto rigorosi (produzione in clean room, microelettronica, misure di igiene). La tuta è altamente impermeabile grazie al tessuto sintetico dotato di una membrana speciale.

Image Unavailable-PRSI91-384

Human recombinant ASGPR1 (from Cells)

Codice catalogo: (PRSI91-384)
Fornitore: ProSci Inc.
Codice articolo fornitore: 91-384
Codice articolo locale: PRSI91-384
Descrizione: Asialoglycoprotein Receptor 1 (ASGPR1) is an endocytic recycling receptor, belongs to the long-form subfamily of the C-type/Ca2+-dependent lectin family. ASGPR consists of two noncovalently-linked subnits, ASGPR1 and ASGPR2. ASGPR1 mediates the endocytosis of plasma glycoproteins, recognizes terminal galactose and N-acetylgalactosamine units. When the ligand binds to to ASGPR1, results in the complex is internalized and transported to a sorting organelle, then ASGPR1 and ligand can be disassociated, ASGPR1 returns to the cell membrane surface.
UOM: 1 * 50 µG
Product Image-PRSI7025

Anti-CLDN4 Rabbit Polyclonal Antibody

Codice catalogo: (PRSI7025)
Fornitore: ProSci Inc.
Codice articolo fornitore: 7025
Codice articolo locale: PRSI7025
Descrizione: CLAUDIN4 Antibody: CLAUDIN4 is an integral membrane protein belonging to the claudin family, a family of cellular adhesion molecules that are components of tight junctions. CLAUDIN4 is a component of tight junction strands and may play a role in internal organ development and function during pre- and postnatal life. The CLAUDIN4 gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems. CLAUDIN4 is frequently overexpressed in ovarian and other epithelial cancers.
UOM: 1 * 100 µG
Product Image-119-0283

Smoking receptacle, Cease Fire®

Codice catalogo: (119-0283)
Fornitore: JUSTRITE MANUFACTURING
Codice articolo fornitore: 26800
Codice articolo locale: JUSU26800
Descrizione: The original smoker’s Cease Fire® cigarette butt receptacle’s self-extinguishing design safely collects unsightly cigarette litter and reduces the risk of fire. Unique rain bonnet opening keeps rain out and discourages other trash. Has a big four gallon galvanised steel pail inside. 'Drip-lip' internal construction prevents tar condensation from escaping, keeping exterior clean from dark, messy drip marks.
UOM: 1 * 1 pezzi
Product Image-IKAA4134400

Immersion circulator, ICC series

Fornitore: IKA
Descrizione: Compact ICC immersion circulators are ideal for tempering of liquids up to 150 °C. Suitable to use in open or covered bath vessels. The integrated pressure/ suction pump allows ICC units to be used for internal and external applications. Just connect the optional pump set. Both units can be used close to ambient temperatures when combined with optional cooling coil. Both models feature optical and acoustic safety warnings and adjustable safety circuit.

Image Unavailable-BOSSBS-7755R

Anti-SEPT9 Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-7755R)
Fornitore: Bioss
Codice articolo fornitore: BS-7755R
Codice articolo locale: BOSSBS-7755R
Descrizione: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.Tissue specificity: Widely expressed. Isoforms are differentially expressed in testes, kidney, liver heart, spleen, brain, peripheral blood leukocytes, skeletal muscle and kidney. Specific isoforms appear to demonstrate tissue specificity. Isoform 5 is the most highly expressed in fetal tissue. Isoform 1 is detected in all tissues except the brain and thymus, while isoform 2, isoform 3, and isoform 4 are detected at low levels in approximately half of the fetal tissues.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13479R-CY3

Anti-GNS Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-13479R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-13479R-CY3
Codice articolo locale: BOSSBS-13479R-CY3
Descrizione: GNS is a 552 amino acid lysosomal enzyme that hydrolyzes the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate and heparan sulfate. A member of the sulfatase family, GNS assists in the catabolism of heparin, and binds calcium as a cofactor. GNS deficiency results in an autosomal recessive lysosomal storage disorder known as mucopolysaccharidosis type IIID (Sanfilippo D syndrome), which is characterized by mild somatic disease and severe degeneration of the central nervous system. Subject to post-translational internal peptidase cleavage, GNS is encoded by a gene mapping to human chromosome 12q14.2 and mouse chromosome 10 D2.
UOM: 1 * 100 µl
Product Image-PRSI27-349

Anti-HDAC6 Rabbit Polyclonal Antibody

Codice catalogo: (PRSI27-349)
Fornitore: ProSci Inc.
Codice articolo fornitore: 27-349
Codice articolo locale: PRSI27-349
Descrizione: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
UOM: 1 * 50 µG
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La disponibilità per questo articolo è limitata, ma potrebbe essere disponibile in un magazzino vicino a voi. Si prega di assicurarsi che si è effettuato l'accesso al sito, in modo che ledisponibilità possano essere visualizzati. Se il call è ancora visualizzato e hai bisogno di assistenza, si prega di telefonare a 1-800-932 - 5000.
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