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Image Unavailable-BOSSBS-6737R-A680

Anti-SVH Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-6737R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-6737R-A680
Codice articolo locale: BOSSBS-6737R-A680
Descrizione: SVH may play a role in cell survival and cell growth and may suppress the transcriptional activity of p53/TP53. Cellular localisation Endoplasmic; reticulum membrane; Single-pass membrane protein.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7647R-HRP

Anti-VDAC1, VDAC2, VDAC3 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-7647R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-7647R-HRP
Codice articolo locale: BOSSBS-7647R-HRP
Descrizione: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13110R-A350

Anti-ETFDH Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-13110R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-13110R-A350
Codice articolo locale: BOSSBS-13110R-A350
Descrizione: Electron-transferring-flavoprotein dehydrogenase in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The protein is synthesized as a 67-kDa precursor which is targeted to mitochondria and processed in a single step to a 64-kDa mature form located in the mitochondrial membrane. Deficiency in electron-transferring-flavoprotein dehydrogenase have been demonstrated in some patients with type II glutaricacidemia. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13110R-CY5

Anti-ETFDH Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-13110R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-13110R-CY5
Codice articolo locale: BOSSBS-13110R-CY5
Descrizione: Electron-transferring-flavoprotein dehydrogenase in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The protein is synthesized as a 67-kDa precursor which is targeted to mitochondria and processed in a single step to a 64-kDa mature form located in the mitochondrial membrane. Deficiency in electron-transferring-flavoprotein dehydrogenase have been demonstrated in some patients with type II glutaricacidemia. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9562R

Anti-LAPTM4A Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-9562R)
Fornitore: Bioss
Codice articolo fornitore: BS-9562R
Codice articolo locale: BOSSBS-9562R
Descrizione: Lysosomal-associated transmembrane protein 4A (LAPTM4A), also known as Golgi 4-transmembrane spanning transporter MTP, is a 233 amino acid protein belonging to the LAPTM5/LAPTM5 transporter family. LAPTM4A is subcellularly localized to the intracytoplasmic membrane and has the potential to reside in intracellular membrane-bound compartments. LAPTM4A is thought to function as a transporter of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of intracellular compartments. LAPTM4A is predicted to have four transmembrane domains, with the C-terminal domain being required for retention of the protein within intracellular membranes.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1558R-A350

Anti-Collagen 7 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-1558R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-1558R-A350
Codice articolo locale: BOSSBS-1558R-A350
Descrizione: Stratified squamous epithelial basement membrane protein that forms anchoring fibrils which may contribute to epithelial basement membrane organization and adherence by interacting with extracellular matrix (ECM) proteins such as type IV collagen.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2945R-A647

Anti-SNX1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-2945R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-2945R-A647
Codice articolo locale: BOSSBS-2945R-A647
Descrizione: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6916R-CY5

Anti-RABX5 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-6916R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-6916R-CY5
Codice articolo locale: BOSSBS-6916R-CY5
Descrizione: Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.
UOM: 1 * 100 µl
Product Image-BE-404

Experimentation kits, hydrophobic and hydrophilic proteins

Codice catalogo: (BE-404)
Fornitore: G-Biosciences
Codice articolo fornitore: BE-404
Codice articolo locale: GENOBE-404
Descrizione: This lab activity is designed to demonstrate the different classes of protein molecules and their classification based on solubility. Students learn fractionation of soluble, insoluble membrane proteins, and cytoskeleton proteins from a tissue sample. The insoluble protein fraction is further fractionated into hydrophilic and hydrophobic membrane proteins. Cell membrane structure and the role of hydrophobic membrane proteins are considered. This lab activity also provides an opportunity to understand characteristics of various classes of detergents and the role of detergents in solubilisation of hydrophobic membrane proteins.
UOM: 1 * 1 KIT
Image Unavailable-BOSSBS-4901R-A647

Anti-ANXA7 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-4901R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-4901R-A647
Codice articolo locale: BOSSBS-4901R-A647
Descrizione: The Annexins are a family of structurally similar proteins. Annexins bind to phospholipids and may be involved in regulation of membrane transport, membrane channel activity, and interaction of the cell membrane with the extracellular matrix. Annexin A7 is a member of the annexin family of calcium dependent phospholipid binding proteins. The Annexin A7 gene contains 14 exons and spans approximately 34 kb of DNA. Structural analysis of the protein suggests that Annexin A7 is a membrane binding protein with diverse properties including voltage sensitive calcium channel activity, ion selectivity and membrane fusion.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9924R-A750

Anti-WDFY3 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-9924R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-9924R-A750
Codice articolo locale: BOSSBS-9924R-A750
Descrizione: WDFY3 was identified in a screen for phosphatidylinositol 3 phosphate binding proteins. The FYVE domain is a zinc binding domain found in many PtdIns binding proteins and is proposed to target proteins to membrane lipids. WDFY3 has been shown localised to the nuclear membrane and within autophagic membranes and it is proposed to function as a link between protein aggregates and the autophagic machinery. WDFY3 is also known as autophagy linked FYVE protein.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11352R-FITC

Anti-MAGI1/IRSP58 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Codice catalogo: (BOSSBS-11352R-FITC)
Fornitore: Bioss
Codice articolo fornitore: BS-11352R-FITC
Codice articolo locale: BOSSBS-11352R-FITC
Descrizione: The membrane-associated guanylate kinase (MAGUK) proteins are concentrated at the membrane-cytoskeletal interface where they facilitate the assembly of multiprotein complexes on the inner surface of the plasma membrane. Three protein-protein interaction modules characteristically define MAGUK related proteins: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. The closely related MAGUK proteins, MAGI-1, MAGI-2 and MAGI-3 (membrane associated guanylate kinase inverted-1 and 2), likewise contain the GuK domain and five PDZ domains; however, the SH3 domain is replaced with a WW domain. The transcripts of MAGI-1 are alternatively spliced to produce three distinct proteins having unique C-terminals. Two variants, MAGI-1a and MAGI-1b, are associated with the membrane and cytosolic fractions and are primarily expressed in the brain. The third isoform, MAGI-1c, encodes for a nuclear localization signal that localizes MAGI-1c to the nucleus, and it is primarily expressed in the liver and kidney. MAGI-2 and MAGI-3 are localized to the plasma membrane, and they contribute to protein scaffolding by associating with the protein phosphatase PTEN.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11352R-A555

Anti-MAGI1/IRSP58 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-11352R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-11352R-A555
Codice articolo locale: BOSSBS-11352R-A555
Descrizione: The membrane-associated guanylate kinase (MAGUK) proteins are concentrated at the membrane-cytoskeletal interface where they facilitate the assembly of multiprotein complexes on the inner surface of the plasma membrane. Three protein-protein interaction modules characteristically define MAGUK related proteins: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. The closely related MAGUK proteins, MAGI-1, MAGI-2 and MAGI-3 (membrane associated guanylate kinase inverted-1 and 2), likewise contain the GuK domain and five PDZ domains; however, the SH3 domain is replaced with a WW domain. The transcripts of MAGI-1 are alternatively spliced to produce three distinct proteins having unique C-terminals. Two variants, MAGI-1a and MAGI-1b, are associated with the membrane and cytosolic fractions and are primarily expressed in the brain. The third isoform, MAGI-1c, encodes for a nuclear localization signal that localizes MAGI-1c to the nucleus, and it is primarily expressed in the liver and kidney. MAGI-2 and MAGI-3 are localized to the plasma membrane, and they contribute to protein scaffolding by associating with the protein phosphatase PTEN.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1461R-A488

Anti-VDAC Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-1461R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-1461R-A488
Codice articolo locale: BOSSBS-1461R-A488
Descrizione: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1461R-CY5.5

Anti-VDAC Rabbit Polyclonal Antibody (Cy5.5®)

Codice catalogo: (BOSSBS-1461R-CY5.5)
Fornitore: Bioss
Codice articolo fornitore: BS-1461R-CY5.5
Codice articolo locale: BOSSBS-1461R-CY5.5
Descrizione: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1461R-A555

Anti-VDAC Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-1461R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-1461R-A555
Codice articolo locale: BOSSBS-1461R-A555
Descrizione: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
UOM: 1 * 100 µl
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