Hai cercato: 2,4-Difluoro-6-hydroxybenzoic+acid+methyl+ester

Codice catalogo: (AATB315)

Fornitore: AAT BIOQUEST

Codice articolo fornitore: 315

Codice articolo locale: AATB315

Descrizione: Compared to fluorescein labeling reagents such as FITC and FAM, 5-dR110 [5-carboxy-4,7-dichlororhodamine 110] reagents give more photostable and pH-independent bioconjugates that have the absorption maximum around the preferred 488 nm excitation wavelength.

UOM: 1 * 25 mg

Promo

Fornitore: BIOPREMIER

Descrizione: SUPREME RT-PCR detection kit HLVd is designed for the detection of Hop Latent Viroid (HLVd) in a single PCR reaction. The kit is suitable for use in real time instruments with FAM and Cy5 detection channels.

Codice catalogo: (51020.)

Fornitore: Biotium

Codice articolo fornitore: 51020

Codice articolo locale: BTIU51020

Descrizione: 6-Carboxyfluorescein has a pKa of 6.5 and can be used as a pH sensor. The excitation spectrum of the dye responds to pH similarly to that of BCECF. Carboxyfluorescein can also be used as a tracer dye. The dye is membrane-impermeant and can be loaded into cells by microinjection or scrape loading.

UOM: 1 * 100 mg

Promo

Codice catalogo: (51019.)

Fornitore: Biotium

Codice articolo fornitore: 51019

Codice articolo locale: BTIU51019

Descrizione: 5-Carboxyfluorescein has a pKa of 6.5 and can be used as a pH sensor. The excitation spectrum of the dye responds to pH similarly to that of BCECF. Carboxyfluorescein can also be used as a tracer dye. The dye is membrane-impermeant and can be loaded into cells by microinjection or scrape loading.

UOM: 1 * 100 mg

Promo

Fornitore: Halyard

Descrizione: Extended length PUREZERO® life science nitrile gloves deliver on all fronts. They are tested against 57 chemicals, with 3 levels of colour-coded protection offering increasing thickness designed for life science applications. The SAFESKIN® manufacturing facility uses 92% renewable energy, dispensers are made with up to 85% recycled materials, and cases are made with up to 99% recycled pulp.

Fornitore: Halyard

Descrizione: Extended length PUREZERO® life science nitrile gloves deliver on all fronts. They are tested against 57 chemicals, with 3 levels of colour-coded protection offering increasing thickness designed for life science applications. The SAFESKIN® manufacturing facility uses 92% renewable energy, dispensers are made with up to 85% recycled materials, and cases are made with up to 99% recycled pulp.

Codice catalogo: (USBI038309-FITC)

Fornitore: US Biological

Codice articolo fornitore: 038309-FITC

Codice articolo locale: USBI038309-FITC

Descrizione: Anti-MECP2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

UOM: 1 * 200 µl

Promo

Codice catalogo: (USBI038240-APC)

Fornitore: US Biological

Codice articolo fornitore: 038240-APC

Codice articolo locale: USBI038240-APC

Descrizione: Anti-MBD4 Rabbit Polyclonal Antibody (APC (Allophycocyanin))

UOM: 1 * 200 µl

Promo

Codice catalogo: (BOSSBS-13025R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-13025R-A647

Codice articolo locale: BOSSBS-13025R-A647

Descrizione: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13025R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-13025R-A555

Codice articolo locale: BOSSBS-13025R-A555

Descrizione: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines residing in the dinucleotide CpG motif, and this methylation results in transcriptional repression of the target gene. The Dnmt enzymes are encoded by independent genes. Dnmt1 is the most abundant, and it preferentially methylates hemimethylated DNA and coordinates gene expression during development. Additional mammalian Dnmt proteins include Dnmt2 and Dnmt3. Dnmt2 lacks the large N-terminal regulator domain of Dnmt1, is expressed at substantially lower levels in adult tissues, and is likely involved in methylating newly integrated retroviral DNA. Dnmt3a and Dnmt3b are encoded by two distinct genes, but both are abundantly expressed in embryonic stem cells, where they also methylate CpG motifs on DNA.

UOM: 1 * 100 µl

Promo

Codice catalogo: (ENZOALX746056M001)

Fornitore: ENZO LIFE SCIENCES

Codice articolo fornitore: ALX746056M001

Codice articolo locale: ENZOALX746056M001

Descrizione: CpG oligodeoxynucleotide (Type B) with phosphorothioate backbone. Specific ligand for human and mouse TLR9 (Toll-like receptor 9).

UOM: 1 * 1 mg

Promo

Codice catalogo: (USBI038232-BIOTIN)

Fornitore: US Biological

Codice articolo fornitore: 038232-BIOTIN

Codice articolo locale: USBI038232-BIOTIN

Descrizione: Anti-MBD2 Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 200 µl

Promo

Codice catalogo: (BOSSBS-5915R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-5915R-A555

Codice articolo locale: BOSSBS-5915R-A555

Descrizione: DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5915R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-5915R-CY3

Codice articolo locale: BOSSBS-5915R-CY3

Descrizione: DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5915R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-5915R-CY5

Codice articolo locale: BOSSBS-5915R-CY5

Descrizione: DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5915R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-5915R-A647

Codice articolo locale: BOSSBS-5915R-A647

Descrizione: DNA methylation, or the addition of methyl groups to cytosine bases in the dinucleotide CpG, is imperative to proper development and regulates gene expression. The methylation pattern involves the enzymatic processes of methylation and demethylation. The demethylation enzyme was recently found to be a mammalian protein, which exhibits demethylase activity associated to a methyl-CpG-binding domain (MBD). The enzyme is able to revert methylated cytosine bases to cytosines within the particular dinucleotide sequence mdCpdG by catalyzing the cleaving of the methyl group as methanol. MeCP2 and MBD1 (PCM1) are first found to repress transcription by binding specifically to methylated DNA. MBD2 and MBD4 (also known as MED1) were later found to colocalize with foci of heavily methylated satellite DNA and believed to mediate the biological functions of the methylation signal. Surprisingly, MBD3 does not bind methylated DNA both in vivo and in vitro. MBD1, MBD2, MBD3, and MBD4 are found to be expressed in somatic tissues, but the expression of MBD1 and MBD2 is reduced or absent in embryonic stem cells, which are known to be deficient in MeCP1 activity. MBD4 have homology to bacterial base excision repair DNA N-glycosylases/lyases. In some microsatellite unstable tumors MBD4 is mutated at an exonic polynucleotide tract.

UOM: 1 * 100 µl

Promo