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Image Unavailable-BOSSBS-3936R-CY3

Anti-SLC27A2 Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-3936R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-3936R-CY3
Codice articolo locale: BOSSBS-3936R-CY3
Descrizione: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2443R-CY5.5

Anti-CYP21A2 Rabbit Polyclonal Antibody (Cy5.5®)

Codice catalogo: (BOSSBS-2443R-CY5.5)
Fornitore: Bioss
Codice articolo fornitore: BS-2443R-CY5.5
Codice articolo locale: BOSSBS-2443R-CY5.5
Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2443R-FITC

Anti-CYP21A2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Codice catalogo: (BOSSBS-2443R-FITC)
Fornitore: Bioss
Codice articolo fornitore: BS-2443R-FITC
Codice articolo locale: BOSSBS-2443R-FITC
Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3967R-HRP

Anti-AMPK beta 1 + 2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-3967R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-3967R-HRP
Codice articolo locale: BOSSBS-3967R-HRP
Descrizione: PRKAB2 ans PRKAB1 are regulatory subunits of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status and plays a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase (ACC). It also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase (HMGCR) and hormone-sensitive lipase. PRKAB2 may be a positive regulator of AMPK activity.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-9036R

Anti-PDZK1 Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-9036R)
Fornitore: Bioss
Codice articolo fornitore: BS-9036R
Codice articolo locale: BOSSBS-9036R
Descrizione: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function.
UOM: 1 * 100 µl
Image Unavailable-228111-5

Colesterolo, Millipore®

Codice catalogo: (228111-5)
Fornitore: Merck Millipore (Calbiochem‎)
Codice articolo fornitore: 228111-5
Codice articolo locale: CALB228111-5
Descrizione: Colesterolo, Millipore®
UOM: 1 * 5 g
Product Image-PRSI30-269

Anti-NSDHL Rabbit Polyclonal Antibody

Codice catalogo: (PRSI30-269)
Fornitore: ProSci Inc.
Codice articolo fornitore: 30-269
Codice articolo locale: PRSI30-269
Descrizione: NSDHL is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis. Mutations in NSDHL gene are associated with CHILD syndrome, which is a X-linked dominant disorder of lipid metabolism with disturbed cholesterol biosynthesis, and typically lethal in males.The protein encoded by this gene is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis. Mutations in this gene are associated with CHILD syndrome, which is a X-linked dominant disorder of lipid metabolism with disturbed cholesterol biosynthesis, and typically lethal in males. Alternatively spliced transcript variants with differing 5' UTR have been found for this gene.
UOM: 1 * 100 µG
Image Unavailable-38302-2.5L

Sodium carbonate : Sodium hydroxide concentrato (150 mM : 15 mM) in water IC eluent concentrate (20x) for Metrosep A Supp 16, Supelco®

Fornitore: Merck
Descrizione: Sodium carbonate : Sodium hydroxide concentrato (150 mM : 15 mM) in water IC eluent concentrate (20x) for Metrosep A Supp 16, Supelco®

Image Unavailable-BOSSBS-3901R-HRP

Anti-CUBN Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-3901R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-3901R-HRP
Codice articolo locale: BOSSBS-3901R-HRP
Descrizione: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
UOM: 1 * 100 µl
Image Unavailable-SPCMCH135-2.5KG

Colesterolo NF

Fornitore: Spectrum Chemical
Descrizione: BSE/TSE statement (available upon request) Allergen statement (available upon request)

Image Unavailable-BOSSBS-13153R-A488

Anti-FDPS Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-13153R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-13153R-A488
Codice articolo locale: BOSSBS-13153R-A488
Descrizione: FDPS is a 419 amino acid enzyme belonging to the FPP/GGPP synthetase family. Localized to cytoplasm and peroxisome, FDPS expression is regulated by phorbol esters and polyunsaturated fatty acids. FDPS assists in cholesterol biosynthesis, post-translational protein modifications and synthesis of steroid hormones in the isoprenoid pathway.FDPS catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FDPS is inactivated by interferon-induced RSAD2, which may result in the disruption of lipid rafts at the plasma membrane. Existing as a homodimer, FDPS may have anti-viral effects when inactivated by RSAD2. Reduced activity of FDPS in liver may partly be the cause of Zellweger syndrome and neonatal adrenoleukodystrophy, both of which are known to be peroxisomal deficiency diseases.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6333R-HRP

Anti-APOB Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-6333R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-6333R-HRP
Codice articolo locale: BOSSBS-6333R-HRP
Descrizione: Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.Involvement in disease: Defects in APOB are a cause of hypobetalipoproteinemia familial type 1 (FHBL1) . A disorder characterized by highly reduced plasma concentrations of low density lipoproteins, and dietary fat malabsorption. Clinical presentation may vary from no symptoms to severe gastrointestinal and neurological dysfunction similar to abetalipoproteinemia.Defects in APOB are a cause of familial ligand-defective apolipoprotein B-100 (FDB). FDB is a dominantly inherited disorder of lipoprotein metabolism leading to hypercholesterolemia and increased proneness to coronary artery disease (CAD). The plasma cholesterol levels are dramatically elevated due to impaired clearance of LDL particles by defective APOB/E receptors.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12928R-A488

Anti-CYP26A1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-12928R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-12928R-A488
Codice articolo locale: BOSSBS-12928R-A488
Descrizione: The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1 is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor ∫2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryos.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12928R-CY3

Anti-CYP26A1 Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-12928R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-12928R-CY3
Codice articolo locale: BOSSBS-12928R-CY3
Descrizione: The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1 is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor ∫2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryos.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12928R

Anti-CYP26A1 Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-12928R)
Fornitore: Bioss
Codice articolo fornitore: BS-12928R
Codice articolo locale: BOSSBS-12928R
Descrizione: The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP26A1 is a major retinoic acid catabolic enzyme. CYP26A1 plays an important role in protecting tailbud tissues from inappropriate exposure to retinoic acid. CYP26A1 transcription is epigenetically regulated by nuclear retinoic acid receptor ∫2. Mutations in the gene encoding for CYP26A1 are associated with caudal agenesis and spina bifida, imperforate anus, agenesis of the caudal portions of the digestive and urogenital tracts, and malformed lumbosacral skeletal elements. CYP26A1 is upregulated in adenomatous polyposis coli mouse adenomas, human FAP adenomas, human sporadic colon carcinomas, and in the intestine of adenomatous polyposis coli (apcmcr) mutant zebrafish embryos.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11296R-CY3

Anti-HSD17B4 Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-11296R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-11296R-CY3
Codice articolo locale: BOSSBS-11296R-CY3
Descrizione: 17Beta-HSD4 (17Beta-hydroxysteroid dehydrogenase type 4) is also known as peroxisomal multifunctional enzyme/protein 2 (MFE-2/MFP-2), D-bifunctional enzyme or 17-Beta Estradiol dehydrogenase type IV. It belongs to the 17Beta-HSD family of proteins that regulate the availability of steroids within various tissues throughout the body. 17Beta-HSD4 inactivates Estradiol through its oxidative activity but it is primarily involved in peroxisomal fatty acid and cholesterol Beta-oxidation. It has a multi-domain structure: the dehydrogenase domain is fused to a hydratase and a lipid transfer domain. 17Beta-HSD4 is a target protein of chromeceptin and it is essential for the downstream activation of Stat6. 17Beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within the first year of life. They display neuronal migration defects, facial dysmorphisms, severe hypotonia and convulsions in the neonatal period.
UOM: 1 * 100 µl
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