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Image Unavailable-BOSSBS-3900R-A350

Anti-CYP2R1 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-3900R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-3900R-A350
Codice articolo locale: BOSSBS-3900R-A350
Descrizione: CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor.Defects in CYP2R1 are a cause of 25-hydroxyvitamin D(3) deficiency, also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity and low levels of 25-hydroxyvitamin D.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11383R-A555

Anti-AACS Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-11383R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-11383R-A555
Codice articolo locale: BOSSBS-11383R-A555
Descrizione: ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11383R-CY7

Anti-AACS Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-11383R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-11383R-CY7
Codice articolo locale: BOSSBS-11383R-CY7
Descrizione: ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11383R

Anti-AACS/ACSF1 Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-11383R)
Fornitore: Bioss
Codice articolo fornitore: BS-11383R
Codice articolo locale: BOSSBS-11383R
Descrizione: ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8718R-CY7

Anti-Viperin Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-8718R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-8718R-CY7
Codice articolo locale: BOSSBS-8718R-CY7
Descrizione: RSAD2 is a 361 amino acid protein that is involved in antiviral defense against pathogens such as Hep C, Cytomegalovirus and HIV-1. Localized to the cytosolic side of the endoplasmic reticulum and relocated to the Golgi apparatus upon viral infection, RSAD2 is thought to prevent viral budding by disrupting lipid rafts at the plasma membrane and supporting the Interferon-induced antiviral state of the cell. Additionally, RSAD2 can bind to and inactivate FDPS (an enzyme that is crucial for the synthesis of cholesterol and geranylated and farnesylated proteins), thereby playing a role in lipid synthesis. Overexpression of RSAD2 leads to abnormal lipid accumulation that is associated with atherosclerosis, a chronic inflammatory disease characterized by hardened arteries.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-8718R-A647

Anti-Viperin Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-8718R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-8718R-A647
Codice articolo locale: BOSSBS-8718R-A647
Descrizione: RSAD2 is a 361 amino acid protein that is involved in antiviral defense against pathogens such as Hep C, Cytomegalovirus and HIV-1. Localized to the cytosolic side of the endoplasmic reticulum and relocated to the Golgi apparatus upon viral infection, RSAD2 is thought to prevent viral budding by disrupting lipid rafts at the plasma membrane and supporting the Interferon-induced antiviral state of the cell. Additionally, RSAD2 can bind to and inactivate FDPS (an enzyme that is crucial for the synthesis of cholesterol and geranylated and farnesylated proteins), thereby playing a role in lipid synthesis. Overexpression of RSAD2 leads to abnormal lipid accumulation that is associated with atherosclerosis, a chronic inflammatory disease characterized by hardened arteries.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12956R-CY7

Anti-ABCA1 Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-12956R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-12956R-CY7
Codice articolo locale: BOSSBS-12956R-CY7
Descrizione: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12956R-FITC

Anti-ABCA1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Codice catalogo: (BOSSBS-12956R-FITC)
Fornitore: Bioss
Codice articolo fornitore: BS-12956R-FITC
Codice articolo locale: BOSSBS-12956R-FITC
Descrizione: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3900R-HRP

Anti-CYP2R1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-3900R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-3900R-HRP
Codice articolo locale: BOSSBS-3900R-HRP
Descrizione: CYP2R1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are mono-oxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is a microsomal vitamin D hydroxylase that converts vitamin D into the active ligand for the vitamin D receptor.Defects in CYP2R1 are a cause of 25-hydroxyvitamin D(3) deficiency, also known as pseudovitamin D(3) deficiency rickets due to 25-hydroxylase deficiency. First described in patients who had rickets at a young age despite a history of adequate vitamin D intake. The patients sera had low calcium concentrations, low phosphate concentrations, elevated alkaline phosphatase activity and low levels of 25-hydroxyvitamin D.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11383R-CY3

Anti-AACS Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-11383R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-11383R-CY3
Codice articolo locale: BOSSBS-11383R-CY3
Descrizione: ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11383R-A680

Anti-AACS/ACSF1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-11383R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-11383R-A680
Codice articolo locale: BOSSBS-11383R-A680
Descrizione: ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3967R-A647

Anti-AMPK beta 1 + 2 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-3967R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-3967R-A647
Codice articolo locale: BOSSBS-3967R-A647
Descrizione: PRKAB2 ans PRKAB1 are regulatory subunits of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status and plays a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase (ACC). It also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase (HMGCR) and hormone-sensitive lipase. PRKAB2 may be a positive regulator of AMPK activity.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3967R-A350

Anti-AMPK beta 1 + 2 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-3967R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-3967R-A350
Codice articolo locale: BOSSBS-3967R-A350
Descrizione: PRKAB2 ans PRKAB1 are regulatory subunits of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status and plays a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase (ACC). It also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase (HMGCR) and hormone-sensitive lipase. PRKAB2 may be a positive regulator of AMPK activity.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3936R-CY7

Anti-SLC27A2 Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-3936R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-3936R-CY7
Codice articolo locale: BOSSBS-3936R-CY7
Descrizione: Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity).
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-2443R-CY5

Anti-CYP21A2 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-2443R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-2443R-CY5
Codice articolo locale: BOSSBS-2443R-CY5
Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in this gene cause congenital adrenal hyperplasia. A related pseudogene is located near this gene; gene conversion events involving the functional gene and the pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
UOM: 1 * 100 µl
Image Unavailable-BIRBORB20952-10

Anti-Cholesterol Esterase Rabbit Polyclonal Antibody

Codice catalogo: (BIRBORB20952-10)
Fornitore: Biorbyt
Codice articolo fornitore: ORB20952-10
Codice articolo locale: BIRBORB20952-10
Descrizione: Anti-Cholesterol Esterase Rabbit Polyclonal Antibody
UOM: 1 * 10 mg

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