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Image Unavailable-BOSSBS-5073R-FITC

Anti-IDI1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Codice catalogo: (BOSSBS-5073R-FITC)
Fornitore: Bioss
Codice articolo fornitore: BS-5073R-FITC
Codice articolo locale: BOSSBS-5073R-FITC
Descrizione: IDI1 is a peroxisomally localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP). These are substrates for the reactions that ultimately result in the synthesis of cholesterol. There is reduction in IPP isomerase activity in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0705R-A647

Anti-LDLR Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-0705R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-0705R-A647
Codice articolo locale: BOSSBS-0705R-A647
Descrizione: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5054R-CY7

Anti-CYP4A11 Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-5054R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-5054R-CY7
Codice articolo locale: BOSSBS-5054R-CY7
Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008].
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-0705R-HRP

Anti-LDLR Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-0705R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-0705R-HRP
Codice articolo locale: BOSSBS-0705R-HRP
Descrizione: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3471R

Anti-VIM Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-3471R)
Fornitore: Bioss
Codice articolo fornitore: BS-3471R
Codice articolo locale: BOSSBS-3471R
Descrizione: Vimentin is the major subunit protein of the intermediate filaments of mesenchymal cells. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain-dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis. Immunohistochemical staining for Vimentin is characteristic of sarcomas (of neural, muscle and fibroblast origin) compared with carcinomas which are generally negative. Melanomas, lymphomas and vascular tumors may all stain for Vimentin. Vimentin are thus of value in the differential diagnosis of undifferentiated neoplasms and malignant tumors. They are generally used with a panel of other including those recognizing cytokeratins, lymphoid markers, S100, desmin and neurofilaments.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3608R-A680

Anti-CYP11A1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-3608R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-3608R-A680
Codice articolo locale: BOSSBS-3608R-A680
Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyse many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localises to the mitochondrial inner membrane and catalyses the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3608R-A488

Anti-CYP11A1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-3608R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-3608R-A488
Codice articolo locale: BOSSBS-3608R-A488
Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15499R-CY3

Anti-CYP2S1 Rabbit Polyclonal Antibody (Cy3)

Codice catalogo: (BOSSBS-15499R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-15499R-CY3
Codice articolo locale: BOSSBS-15499R-CY3
Descrizione: CYP2S1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyse many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localises to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolise certain carcinogens; however, the specific function of the human protein has not been determined.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-15499R-CY7

Anti-CYP2S1 Rabbit Polyclonal Antibody (Cy7)

Codice catalogo: (BOSSBS-15499R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-15499R-CY7
Codice articolo locale: BOSSBS-15499R-CY7
Descrizione: CYP2S1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyse many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localises to the endoplasmic reticulum. In rodents, the homologous protein has been shown to metabolise certain carcinogens; however, the specific function of the human protein has not been determined.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13687R-HRP

Anti-LAMTOR1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-13687R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-13687R-HRP
Codice articolo locale: BOSSBS-13687R-HRP
Descrizione: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3862R-A555

Anti-SCAP Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-3862R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-3862R-A555
Codice articolo locale: BOSSBS-3862R-A555
Descrizione: SCAP is an escort protein required for cholestrol and lipid homeostasis. Cholesterol homeostasis in animal cells is achieved by regulated cleavage of SREBPs, membrane-bound transcription factors. SCAP forms a complex with SREBPs in order to release the active domains of SREBPs.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11426R-A555

Anti-FDX1 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-11426R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-11426R-A555
Codice articolo locale: BOSSBS-11426R-A555
Descrizione: Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-1627R-HRP

Anti-ABCA1/ABC1 Rabbit Polyclonal Antibody (HRP (Horseradish PE (Phycoerythrin)rOxidase))

Codice catalogo: (BOSSBS-1627R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-1627R-HRP
Codice articolo locale: BOSSBS-1627R-HRP
Descrizione: cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3919R-CY3

Anti-STARD5 Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-3919R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-3919R-CY3
Codice articolo locale: BOSSBS-3919R-CY3
Descrizione: STARD5, or START domain containing 5, belongs to a family containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain. STARD5 may be involved in the intracellular transport of sterols or other lipids and may bind cholesterol or other sterols.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3919R-CY5

Anti-STARD5 Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-3919R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-3919R-CY5
Codice articolo locale: BOSSBS-3919R-CY5
Descrizione: STARD5, or START domain containing 5, belongs to a family containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain. STARD5 may be involved in the intracellular transport of sterols or other lipids and may bind cholesterol or other sterols.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3223R-CY3

Anti-LIPE Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-3223R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-3223R-CY3
Codice articolo locale: BOSSBS-3223R-CY3
Descrizione: HSL/LIPE is found in adipose tissue and heart, where it primarily hydrolyzes stored triglycerides to free fatty acids. It is also found in steroidogenic tissues, where it principally converts cholesteryl esters to free cholesterol for steroid hormone production. There are two named isoforms.
UOM: 1 * 100 µl
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