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Image Unavailable-BOSSBS-5013R-A750

Anti-ABCG5 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-5013R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-5013R-A750
Codice articolo locale: BOSSBS-5013R-A750
Descrizione: Transporter that appears to play an indispensable role in the selective transport of the dietary cholesterol in and out of the enterocytes and in the selective sterol excretion by the liver into bile.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5050R-A750

Anti-CYP39A1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-5050R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-5050R-A750
Codice articolo locale: BOSSBS-5050R-A750
Descrizione: The CYP39A1 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyse many reactions involved in drug metabolism and synthesis of steroids, cholesterol and other lipids. This endoplasmic reticulum protein is involved in the conversion of cholesterol to bile acids. Its substrates include the oxysterols 25-hydroxycholesterol, 27-hydroxycholesterol and 24-hydroxycholesterol.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11549R-A647

Anti-DISP1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-11549R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-11549R-A647
Codice articolo locale: BOSSBS-11549R-A647
Descrizione: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11549R-A488

Anti-DISP1 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-11549R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-11549R-A488
Codice articolo locale: BOSSBS-11549R-A488
Descrizione: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-4063R-FITC

Anti-HMGCR Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Codice catalogo: (BOSSBS-4063R-FITC)
Fornitore: Bioss
Codice articolo fornitore: BS-4063R-FITC
Codice articolo locale: BOSSBS-4063R-FITC
Descrizione: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-5068R-A680

Anti-HMGCR Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Codice catalogo: (BOSSBS-5068R-A680)
Fornitore: Bioss
Codice articolo fornitore: BS-5068R-A680
Codice articolo locale: BOSSBS-5068R-A680
Descrizione: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-10130R-CY7

Anti-APOD Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-10130R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-10130R-CY7
Codice articolo locale: BOSSBS-10130R-CY7
Descrizione: APOD occurs in the macromolecular complex with lecithin-cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-13687R

Anti-LAMTOR1 Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-13687R)
Fornitore: Bioss
Codice articolo fornitore: BS-13687R
Codice articolo locale: BOSSBS-13687R
Descrizione: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.
UOM: 1 * 100 µl
Image Unavailable-1131960.

Cholesterol, Reference Standard

Codice catalogo: (1131960.)
Fornitore: USP
Codice articolo fornitore: 1131960
Codice articolo locale: USPH1131960
Descrizione: USP Reference Standards are specified for use in conducting official USP–NF tests and assays. USP also provides Reference Standards specified in the Food Chemicals Codex as well as authentic substances—high-quality chemical samples—as a service to analytical, clinical, pharmaceutical and research laboratories. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.
UOM: 1 * 125 mg

Certificati


Image Unavailable-CAYM71820-10

Calcitriol ≥97%, crystalline solid

Fornitore: Cayman Chemical
Descrizione: Calcitriol is synthesised from 7-dehydro cholesterol in humans by a non-enzymatic photochemical reaction with 290 to 310 nm UV light in the skin.

Image Unavailable-BOSSBS-12501R-A750

Anti-ApoM/Apolipoprotein M Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-12501R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-12501R-A750
Codice articolo locale: BOSSBS-12501R-A750
Descrizione: Apolipoproteins are protein components of plasma lipoproteins. ApoM (Apolipoprotein M), also known as protein G3a, is a member of the Lipocalin family of proteins. ApoM is exclusively expressed in kidney tubular epithelial cells and liver hepatocytes. Mature ApoM retains its signal peptide, which acts as a hydrophobic anchor, and contains a structurally conserved eight stranded antiparallel barrel which binds retinol and retinoic acid. ApoM may play a key role in reverse cholesterol transport. It mainly associates with high density lipoprotein (HDL) and to a lesser extent with triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). ApoM is important for the pre-HDL formation. Pre-HDL is an important acceptor of peripheral cellular cholesterol. The concentration of ApoM in plasma strongly correlates with total cholesterol. Low concentrations of ApoM in plasma is associated with diabetes.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12501R-CY5

Anti-APOM Rabbit Polyclonal Antibody (Cy5®)

Codice catalogo: (BOSSBS-12501R-CY5)
Fornitore: Bioss
Codice articolo fornitore: BS-12501R-CY5
Codice articolo locale: BOSSBS-12501R-CY5
Descrizione: Apolipoproteins are protein components of plasma lipoproteins. ApoM (Apolipoprotein M), also known as protein G3a, is a member of the Lipocalin family of proteins. ApoM is exclusively expressed in kidney tubular epithelial cells and liver hepatocytes. Mature ApoM retains its signal peptide, which acts as a hydrophobic anchor, and contains a structurally conserved eight stranded antiparallel ∫ barrel which binds retinol and retinoic acid. ApoM may play a key role in reverse cholesterol transport. It mainly associates with high density lipoprotein (HDL) and to a lesser extent with triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). ApoM is important for the pre∫-HDL formation. Pre∫-HDL is an important acceptor of peripheral cellular cholesterol. The concentration of ApoM in plasma strongly correlates with total cholesterol. Low concentrations of ApoM in plasma is associated with diabetes.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12501R-CY7

Anti-APOM Rabbit Polyclonal Antibody (Cy7®)

Codice catalogo: (BOSSBS-12501R-CY7)
Fornitore: Bioss
Codice articolo fornitore: BS-12501R-CY7
Codice articolo locale: BOSSBS-12501R-CY7
Descrizione: Apolipoproteins are protein components of plasma lipoproteins. ApoM (Apolipoprotein M), also known as protein G3a, is a member of the Lipocalin family of proteins. ApoM is exclusively expressed in kidney tubular epithelial cells and liver hepatocytes. Mature ApoM retains its signal peptide, which acts as a hydrophobic anchor, and contains a structurally conserved eight stranded antiparallel ∫ barrel which binds retinol and retinoic acid. ApoM may play a key role in reverse cholesterol transport. It mainly associates with high density lipoprotein (HDL) and to a lesser extent with triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). ApoM is important for the pre∫-HDL formation. Pre∫-HDL is an important acceptor of peripheral cellular cholesterol. The concentration of ApoM in plasma strongly correlates with total cholesterol. Low concentrations of ApoM in plasma is associated with diabetes.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-6560R-CY3

Anti-OSBP2 Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-6560R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-6560R-CY3
Codice articolo locale: BOSSBS-6560R-CY3
Descrizione: The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3608R-A750

Anti-CYP11A1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Codice catalogo: (BOSSBS-3608R-A750)
Fornitore: Bioss
Codice articolo fornitore: BS-3608R-A750
Codice articolo locale: BOSSBS-3608R-A750
Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyse many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localises to the mitochondrial inner membrane and catalyses the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-3608R-A647

Anti-CYP11A1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-3608R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-3608R-A647
Codice articolo locale: BOSSBS-3608R-A647
Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, the first and rate-limiting step in the synthesis of the steroid hormones. Two transcript variants encoding different isoforms have been found for this gene. The cellular location of the smaller isoform is unclear since it lacks the mitochondrial-targeting transit peptide. [provided by RefSeq, Jul 2008]
UOM: 1 * 100 µl
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