Hai cercato: Cholesterol+margarate

Codice catalogo: (BOSSBS-10161R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-10161R-A555

Codice articolo locale: BOSSBS-10161R-A555

Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-10161R)

Fornitore: Bioss

Codice articolo fornitore: BS-10161R

Codice articolo locale: BOSSBS-10161R

Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

Promo

Codice catalogo: (PRSI96-031)

Fornitore: ProSci Inc.

Codice articolo fornitore: 96-031

Codice articolo locale: PRSI96-031

Descrizione: ApoA1 is also known as apolipoprotein A-I, ApoA-I , and is the major protein component of high density lipoprotein (HDL) in plasma. It has a specific role in lipid metabolism. Chylomicrons secreted from the intestinal enterocyte also contain ApoA1 but it is quickly transferred to HDL in the bloodstream. The protein promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterol acyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. ApoA-I was also isolated as a prostacyclin (PGI2) stabilizing factor, and thus may have an anticlotting effect. Defects in the gene encoding it are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. In addition, it has been shown that ApoA1 is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.

UOM: 1 * 50 µG

Promo

Codice catalogo: (BOSSBS-10161R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-10161R-A350

Codice articolo locale: BOSSBS-10161R-A350

Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

Promo

Codice catalogo: (PRSI96-673)

Fornitore: ProSci Inc.

Codice articolo fornitore: 96-673

Codice articolo locale: PRSI96-673

Descrizione: Scavenger receptor class B member 1 (SRB1) is also known as SR-BI, CD36 and LIMPII analogous 1 (CD36L1), CLA-1, is a member of the scavenger receptor family or CD36 family. CD36L1 is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. SRB1 is receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. CLA-1 facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high-density lipoprotein (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus glycoprotein E2 in liver cells, and binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. SRB1 plays an important role in the uptake of HDL cholesteryl ester.

UOM: 1 * 50 µG

Promo

Codice catalogo: (PRSI36-084)

Fornitore: ProSci Inc.

Codice articolo fornitore: 36-084

Codice articolo locale: PRSI36-084

Descrizione: FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.

UOM: 1 * 100 µG

Promo

Codice catalogo: (PRSI5193)

Fornitore: ProSci Inc.

Codice articolo fornitore: 5193

Codice articolo locale: PRSI5193

Descrizione: SCARB1 Antibody: Scavenger receptor class B member 1 (SCARB1), also known as SR-BI, is part of the scavenger receptor superfamily, which is composed of many members with diverse structures, expression patterns, and functions. SCARB1 is a multi-ligand cell-surface receptor that mediates the selective uptake of lipid from HDL cholesterol into cells and is expressed in steroidogenic tissues in adult animals. Other ligands of SCARB1 include native, acetylated, or oxidized LDL and anionic phospholipids. SCARB1-deficient mice have elevated HDL levels and increased susceptibility to atherosclerosis on fat feeding, indicating its importance in the regulation of cholesterol homeostasis. Along with CLDN1, LDL-R, and the tetraspanin superfamily member CD81, SCARB1 has been reported to be an entry factor for the Hepatitis C virus. At least two isoforms of SCARB1 are known to exist.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BOSSBS-3472R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-3472R-A680

Codice articolo locale: BOSSBS-3472R-A680

Descrizione: This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilising cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organiser of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9674R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-9674R-CY7

Codice articolo locale: BOSSBS-9674R-CY7

Descrizione: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

UOM: 1 * 100 µl

Promo

Codice catalogo: (PRSI56-769)

Fornitore: ProSci Inc.

Codice articolo fornitore: 56-769

Codice articolo locale: PRSI56-769

Descrizione: This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

UOM: 1 * 400 µl

Promo

Codice catalogo: (BOSSBS-10161R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-10161R-A647

Codice articolo locale: BOSSBS-10161R-A647

Descrizione: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008].

UOM: 1 * 100 µl

Promo

Codice catalogo: (PRSI91-228)

Fornitore: ProSci Inc.

Codice articolo fornitore: 91-228

Codice articolo locale: PRSI91-228

Descrizione: Phosphomevalonate kinase (PMVK) is a cytosolic enzyme. PMVK can be highly expressed in the heart,skeletal muscle, liver, pancreas, and kidney; it is expressed at lower levels in the brain, lung, and placenta. Induced by sterol, PMVK takes part in isopentenyl diphosphate biosynthesis through the mevalonate pathway. PMVK catalyses the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate in the fifth reaction of the cholesterol biosynthetic pathway.

UOM: 1 * 50 µG

Promo

Codice catalogo: (BOSSBS-9674R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-9674R-A350

Codice articolo locale: BOSSBS-9674R-A350

Descrizione: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9674R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-9674R-CY5.5

Codice articolo locale: BOSSBS-9674R-CY5.5

Descrizione: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3472R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-3472R-A750

Codice articolo locale: BOSSBS-3472R-A750

Descrizione: This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-9674R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-9674R-A750

Codice articolo locale: BOSSBS-9674R-A750

Descrizione: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilisation of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR.

UOM: 1 * 100 µl

Promo