Hai cercato: Cholesterol+margarate

Codice catalogo: (BOSSBS-4063R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-4063R-CY3

Codice articolo locale: BOSSBS-4063R-CY3

Descrizione: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4063R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-4063R-A488

Codice articolo locale: BOSSBS-4063R-A488

Descrizione: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5068R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-5068R-A350

Codice articolo locale: BOSSBS-5068R-A350

Descrizione: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3862R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-3862R-A488

Codice articolo locale: BOSSBS-3862R-A488

Descrizione: SCAP is an escort protein required for cholestrol and lipid homeostasis. Cholesterol homeostasis in animal cells is achieved by regulated cleavage of SREBPs, membrane-bound transcription factors. SCAP forms a complex with SREBPs in order to release the active domains of SREBPs.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3862R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-3862R-FITC

Codice articolo locale: BOSSBS-3862R-FITC

Descrizione: SCAP is an escort protein required for cholestrol and lipid homeostasis. Cholesterol homeostasis in animal cells is achieved by regulated cleavage of SREBPs, membrane-bound transcription factors. SCAP forms a complex with SREBPs in order to release the active domains of SREBPs.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11426R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-11426R-A350

Codice articolo locale: BOSSBS-11426R-A350

Descrizione: Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3919R)

Fornitore: Bioss

Codice articolo fornitore: BS-3919R

Codice articolo locale: BOSSBS-3919R

Descrizione: STARD5, or START domain containing 5, belongs to a family containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain. STARD5 may be involved in the intracellular transport of sterols or other lipids and may bind cholesterol or other sterols.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3223R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-3223R-CY5.5

Codice articolo locale: BOSSBS-3223R-CY5.5

Descrizione: HSL/LIPE is found in adipose tissue and heart, where it primarily hydrolyzes stored triglycerides to free fatty acids. It is also found in steroidogenic tissues, where it principally converts cholesteryl esters to free cholesterol for steroid hormone production. There are two named isoforms.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4063R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-4063R-HRP

Codice articolo locale: BOSSBS-4063R-HRP

Descrizione: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-8328R)

Fornitore: Bioss

Codice articolo fornitore: BS-8328R

Codice articolo locale: BOSSBS-8328R

Descrizione: SMEK2 contains a WH1 domain. There are five named isoforms produced by alternative splicing. Mapping of a diet-induced hypercholesterolemia locus (Dihc2) in rats identified SMEK2 as a strong candidate for responsiveness to dietary cholesterol.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6339R)

Fornitore: Bioss

Codice articolo fornitore: BS-6339R

Codice articolo locale: BOSSBS-6339R

Descrizione: High density lipoprotein-binding protein, HDLBP, also known as vigilin, specifically binds HDL molecules and may function in the removal of excess cellular cholesterol. It may also be involved in the regulation of the delivery of fats to cells for energy and storage as fats in the bloodstream are not readily metabolized in the absence of HDLBP.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11426R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-11426R-CY7

Codice articolo locale: BOSSBS-11426R-CY7

Descrizione: Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6560R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-6560R-A488

Codice articolo locale: BOSSBS-6560R-A488

Descrizione: The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6560R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-6560R-CY5.5

Codice articolo locale: BOSSBS-6560R-CY5.5

Descrizione: The Oxysterol-binding protein (OSBP) family of proteins consist of OSBP (OSBP1) and OSBP2 (ORP-4), which share a high overall similarity. OSBPs are involved in lipid metabolism and signal transduction, as well as vesicle transport, and can translocate to the periphery of Golgi membranes when they are bound to oxysterols. The OSBP protein transports sterols from lysosomes to the nucleus, where sterols downregulate the genes for HMG synthetase, HMG-CoA reductase and the low density lipoprotein receptor (LDLR). OSBP localizes to the cytosol and is widely expressed, while OSBP2 is mainly detected in testis, retina and fetal liver. The extracellular signal-regulated kinase (ERK) signaling pathway is controlled by OSBP via its cholesterol-binding properties. OSBP binds with a high affinity to 25-hydroxy-cholesterol (25-HC), a suppressor of cholesterol synthesis gene transcription in cultured cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12501R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-12501R-FITC

Codice articolo locale: BOSSBS-12501R-FITC

Descrizione: Apolipoproteins are protein components of plasma lipoproteins. ApoM (Apolipoprotein M), also known as protein G3a, is a member of the Lipocalin family of proteins. ApoM is exclusively expressed in kidney tubular epithelial cells and liver hepatocytes. Mature ApoM retains its signal peptide, which acts as a hydrophobic anchor, and contains a structurally conserved eight stranded antiparallel ∫ barrel which binds retinol and retinoic acid. ApoM may play a key role in reverse cholesterol transport. It mainly associates with high density lipoprotein (HDL) and to a lesser extent with triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). ApoM is important for the pre∫-HDL formation. Pre∫-HDL is an important acceptor of peripheral cellular cholesterol. The concentration of ApoM in plasma strongly correlates with total cholesterol. Low concentrations of ApoM in plasma is associated with diabetes.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2200R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-2200R-A750

Codice articolo locale: BOSSBS-2200R-A750

Descrizione: LDL and HDL transport both dietary and endogenous cholesterol in the plasma. LDL is the main transporter of cholesterol and cholesteryl esters and makes up more than half of the total lipoprotein in plasma. LDL is absorbed by the liver and other tissues via receptor mediated endocytosis. The cytoplasmic domain of the LDL receptor facilitates the formation of coated pits; receptor-rich regions of the membrane. The ligand binding domain of the receptor Recognises apo-B100 on LDL, resulting in the formation of a clathrin-coated vesicle. ATP-dependent proton pumps lower the pH inside the vesicle resulting dissociation of LDL from its receptor. After loss of the clathrin coat the vesicles fuse with lysozomes, resulting in peptide and cholesteryl ester enzymatic hydrolysis. The LDL receptor can be recycled to the cell membrane. Insulin, tri-iodothyronine and dexamethasome have shown to be involved with the regulation of LDL receptor mediated uptake. The protein component of LDL is apolipoprotein B100. LDL contains 2022% protein, 1015% triglycerides, 2028% phospholipids, 3748% cholesteryl esters and 810% cholesterol.

UOM: 1 * 100 µl

Promo