Hai cercato: C6+NBD-Ceramide

Codice catalogo: (BOSSBS-12976R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-12976R-CY3

Codice articolo locale: BOSSBS-12976R-CY3

Descrizione: Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.

UOM: 1 * 100 µl

Promo

Codice catalogo: (USBI135992)

Fornitore: US Biological

Codice articolo fornitore: 135992

Codice articolo locale: USBI135992

Descrizione: Anti-C6 Mouse Monoclonal Antibody

UOM: 1 * 50 µG

Promo

Codice catalogo: (BOSSBS-6021R)

Fornitore: Bioss

Codice articolo fornitore: BS-6021R

Codice articolo locale: BOSSBS-6021R

Descrizione: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.

UOM: 1 * 100 µl

Promo

Codice catalogo: (ABCAAB74638-100)

Fornitore: Abcam

Codice articolo fornitore: AB74638-100

Codice articolo locale: ABCAAB74638-100

Descrizione: Anti-C6 Rabbit Polyclonal Antibody

UOM: 1 * 100 µG

Promo

Codice catalogo: (USBIC7850-35G-BIOT)

Fornitore: US Biological

Codice articolo fornitore: C7850-35G-BIOT

Codice articolo locale: USBIC7850-35G-BIOT

Descrizione: Anti-C6 Rabbit Polyclonal Antibody (Biotin)

UOM: 1 * 200 µl

Promo

Codice catalogo: (USBIC7850-35E)

Fornitore: US Biological

Codice articolo fornitore: C7850-35E

Codice articolo locale: USBIC7850-35E

Descrizione: Anti-C6 Mouse Monoclonal Antibody [clone: 10B400]

UOM: 1 * 100 µG

Promo

Codice catalogo: (USBI137889)

Fornitore: US Biological

Codice articolo fornitore: 137889

Codice articolo locale: USBI137889

Descrizione: Anti-C6 Goat Polyclonal Antibody

UOM: 1 * 1 mL

Promo

Codice catalogo: (BOSSBS-6873R)

Fornitore: Bioss

Codice articolo fornitore: BS-6873R

Codice articolo locale: BOSSBS-6873R

Descrizione: This gene was initially identified as a locus (RP26) associated with an autosomal recessive form of retinitis pigmentosa (arRP) disease. This gene encodes a protein with ceramide kinase-like domains, however, the protein does not phosphorylate ceramide and its target substrate is currently unknown. This protein may be a negative regulator of apoptosis in photoreceptor cells. Mutations in this gene cause a form of retinitis pigmentosa characterized by autosomal recessive cone and rod dystrophy (arCRD). Alternative splicing of this gene results in multiple transcript variants encoding different isoforms and non-coding transcripts.[provided by RefSeq, May 2010].

UOM: 1 * 100 µl

Promo

Codice catalogo: (ABCAAB239495-100)

Fornitore: Abcam

Codice articolo fornitore: AB239495-100

Codice articolo locale: ABCAAB239495-100

Descrizione: Anti-Hemojuvelin Mouse Monoclonal Antibody [clone: C6]

UOM: 1 * 100 µG

Promo

Codice catalogo: (ABCAAB239501-100)

Fornitore: Abcam

Codice articolo fornitore: AB239501-100

Codice articolo locale: ABCAAB239501-100

Descrizione: Anti-Galectin 2 Mouse Monoclonal Antibody [clone: C6]

UOM: 1 * 100 µG

Promo

Codice catalogo: (BOSSBS-5082R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-5082R-FITC

Codice articolo locale: BOSSBS-5082R-FITC

Descrizione: Lass5, or LAG1 longevity assurance homolog 5, is thought to be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor ceramide) in a fumonisin B1-independent manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5082R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-5082R-A350

Codice articolo locale: BOSSBS-5082R-A350

Descrizione: Lass5, or LAG1 longevity assurance homolog 5, is thought to be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor ceramide) in a fumonisin B1-independent manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (TCIAS0451-5ML)

Fornitore: TCI

Codice articolo fornitore: S0451-5ML

Codice articolo locale: TCIAS0451-5ML

Descrizione: Standard Mixture of n-Paraffins (consists of C5, C6, C7, C8 and C9)

UOM: 1 * 5 mL

Promo

Codice catalogo: (USBIC7850-35G-HRP)

Fornitore: US Biological

Codice articolo fornitore: C7850-35G-HRP

Codice articolo locale: USBIC7850-35G-HRP

Descrizione: Anti-C6 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

UOM: 1 * 200 µl

Promo

Codice catalogo: (APOSBISN0156-10MG)

Fornitore: Apollo Scientific

Codice articolo fornitore: BISN0156-10MG

Codice articolo locale: APOSBISN0156-10MG

Descrizione: GW4869 2HCl is a cell permeable, selective and non-competitve inhibitor of N-SMase (neutral sphingomyelinase), which is important in the metabolism of sphingomyelin producing ceramide and phosphocholine and in cell signaling and regulation.

UOM: 1 * 10 mg

Promo

Codice catalogo: (BOSSBS-4216R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-4216R-A350

Codice articolo locale: BOSSBS-4216R-A350

Descrizione: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

UOM: 1 * 100 µl

Promo