Hai cercato: C6+NBD-Ceramide

Codice catalogo: (BOSSBS-12976R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-12976R-HRP

Codice articolo locale: BOSSBS-12976R-HRP

Descrizione: Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12976R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-12976R-A555

Codice articolo locale: BOSSBS-12976R-A555

Descrizione: Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.

UOM: 1 * 100 µl

Promo

Codice catalogo: (ABGEAP6937A)

Fornitore: Abgent

Codice articolo fornitore: AP6937A

Codice articolo locale: ABGEAP6937A

Descrizione: Anti-C6 Rabbit Polyclonal Antibody

UOM: 1 * 400 µl

Promo

Codice catalogo: (BOSSBS-5082R)

Fornitore: Bioss

Codice articolo fornitore: BS-5082R

Codice articolo locale: BOSSBS-5082R

Descrizione: Lass5, or LAG1 longevity assurance homolog 5, is thought to be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor ceramide) in a fumonisin B1-independent manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (USBIC7850-35G)

Fornitore: US Biological

Codice articolo fornitore: C7850-35G

Codice articolo locale: USBIC7850-35G

Descrizione: Anti-C6 Rabbit Polyclonal Antibody

UOM: 1 * 200 µl

Promo

Codice catalogo: (60025.)

Fornitore: Biotium

Codice articolo fornitore: 60025

Codice articolo locale: BTIU60025

Descrizione: NBD-PE (N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)-1,2-dihexadecanoyl-snglycero-3-phosphoethanolamine, triethylammonium salt) in combination with Rhodamine-DHPE (#60026) or Texas Red®-DHPE (#60027) has been used to study membrane fusion via fluorescence resonance energy transfer (FRET) (1-3). NBD-PE has also been used in photobleaching recovery measurement.

UOM: 1 * 10 mg

Promo

Codice catalogo: (BOSSBS-5082R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-5082R-CY3

Codice articolo locale: BOSSBS-5082R-CY3

Descrizione: Lass5, or LAG1 longevity assurance homolog 5, is thought to be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor ceramide) in a fumonisin B1-independent manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4216R-CY5.5)

Fornitore: Bioss

Codice articolo fornitore: BS-4216R-CY5.5

Codice articolo locale: BOSSBS-4216R-CY5.5

Descrizione: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-4216R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-4216R-A750

Codice articolo locale: BOSSBS-4216R-A750

Descrizione: Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically Recognises the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5082R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-5082R-A680

Codice articolo locale: BOSSBS-5082R-A680

Descrizione: Lass5, or LAG1 longevity assurance homolog 5, is thought to be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor ceramide) in a fumonisin B1-independent manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5077R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-5077R-A750

Codice articolo locale: BOSSBS-5077R-A750

Descrizione: LASS2 (LAG1 homolog, ceramide synthase 2) has sequence similarity to yeast longevity assurance gene 1. It is thought to be involved in sphingolipid synthesis. Expression of LASS2 is transiently increased during the period of active myelination and is specifically localised to white matter tracts of the brain, including the Schwann cells of sciatic nerves suggesting that LASS2 is important for the synthesis of dihydroceramide used for synthesis of myelin sphingolipids. Expression of LASS2 in hepatocellular carcinoma cell lines suppresses the growth of cancer cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5082R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-5082R-A647

Codice articolo locale: BOSSBS-5082R-A647

Descrizione: Lass5, or LAG1 longevity assurance homolog 5, is thought to be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor ceramide) in a fumonisin B1-independent manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (634-1142)

Fornitore: VWR Collection

Codice articolo locale: VWRI634-1142

Descrizione: Accessory for UV/Visible spectrophotometers, Tungsten lamp, USHIO JC12V-20W/G4 C6, VWR®

UOM: 1 * 1 pezzi

Promo

Codice catalogo: (USBIC7850-35G-FITC)

Fornitore: US Biological

Codice articolo fornitore: C7850-35G-FITC

Codice articolo locale: USBIC7850-35G-FITC

Descrizione: Anti-C6 Rabbit Polyclonal Antibody (FITC (Fluorescein))

UOM: 1 * 200 µl

Promo

Codice catalogo: (BOSSBS-4277R)

Fornitore: Bioss

Codice articolo fornitore: BS-4277R

Codice articolo locale: BOSSBS-4277R

Descrizione: Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12976R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-12976R-CY3

Codice articolo locale: BOSSBS-12976R-CY3

Descrizione: Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.

UOM: 1 * 100 µl

Promo