Hai cercato: C6+NBD-Ceramide

Codice catalogo: (BOSSBS-12976R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-12976R-A488

Codice articolo locale: BOSSBS-12976R-A488

Descrizione: Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5082R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-5082R-HRP

Codice articolo locale: BOSSBS-5082R-HRP

Descrizione: Lass5, or LAG1 longevity assurance homolog 5, is thought to be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor ceramide) in a fumonisin B1-independent manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5044R)

Fornitore: Bioss

Codice articolo fornitore: BS-5044R

Codice articolo locale: BOSSBS-5044R

Descrizione: Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5077R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-5077R-A750

Codice articolo locale: BOSSBS-5077R-A750

Descrizione: LASS2 (LAG1 homolog, ceramide synthase 2) has sequence similarity to yeast longevity assurance gene 1. It is thought to be involved in sphingolipid synthesis. Expression of LASS2 is transiently increased during the period of active myelination and is specifically localised to white matter tracts of the brain, including the Schwann cells of sciatic nerves suggesting that LASS2 is important for the synthesis of dihydroceramide used for synthesis of myelin sphingolipids. Expression of LASS2 in hepatocellular carcinoma cell lines suppresses the growth of cancer cells.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5044R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-5044R-A750

Codice articolo locale: BOSSBS-5044R-A750

Descrizione: Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12976R-CY5)

Fornitore: Bioss

Codice articolo fornitore: BS-12976R-CY5

Codice articolo locale: BOSSBS-12976R-CY5

Descrizione: Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12976R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-12976R-FITC

Codice articolo locale: BOSSBS-12976R-FITC

Descrizione: Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12976R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-12976R-A350

Codice articolo locale: BOSSBS-12976R-A350

Descrizione: Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12976R-A647)

Fornitore: Bioss

Codice articolo fornitore: BS-12976R-A647

Codice articolo locale: BOSSBS-12976R-A647

Descrizione: Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5082R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-5082R-A555

Codice articolo locale: BOSSBS-5082R-A555

Descrizione: Lass5, or LAG1 longevity assurance homolog 5, is thought to be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor ceramide) in a fumonisin B1-independent manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5082R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-5082R-CY7

Codice articolo locale: BOSSBS-5082R-CY7

Descrizione: Lass5, or LAG1 longevity assurance homolog 5, is thought to be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donnor ceramide) in a fumonisin B1-independent manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-12976R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-12976R-CY3

Codice articolo locale: BOSSBS-12976R-CY3

Descrizione: Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.

UOM: 1 * 100 µl

Promo

Codice catalogo: (AATB829)

Fornitore: AAT BIOQUEST

Codice articolo fornitore: 829

Codice articolo locale: AATB829

Descrizione: Compared to NBD chloride and fluoride, NBD-X acid gives better yield for labeling biopolymers.

UOM: 1 * 100 mg

Promo

Codice catalogo: (BOSSBS-5044R-CY3)

Fornitore: Bioss

Codice articolo fornitore: BS-5044R-CY3

Codice articolo locale: BOSSBS-5044R-CY3

Descrizione: Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-5044R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-5044R-CY7

Codice articolo locale: BOSSBS-5044R-CY7

Descrizione: Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-6021R)

Fornitore: Bioss

Codice articolo fornitore: BS-6021R

Codice articolo locale: BOSSBS-6021R

Descrizione: Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6.5-8.5. Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface. Acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine, a precursor of the antiapoptotic factor sphingosine 1-phosphate. Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract.

UOM: 1 * 100 µl

Promo