Hai cercato: (±)-Camphor-10-sulphonic+acid

Codice catalogo: (BOSSBS-2752R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-2752R-A750

Codice articolo locale: BOSSBS-2752R-A750

Descrizione: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2752R-A555)

Fornitore: Bioss

Codice articolo fornitore: BS-2752R-A555

Codice articolo locale: BOSSBS-2752R-A555

Descrizione: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

Promo

Fornitore: Lenz Laborglas GmbH & CO.KG

Descrizione: Capacità: -

Fornitore: Lenz Laborglas GmbH & CO.KG

Descrizione: Gas distribution tubes with lateral ring made of borosilicate glass 3,3.

Codice catalogo: (BOSSBS-2752R-A680)

Fornitore: Bioss

Codice articolo fornitore: BS-2752R-A680

Codice articolo locale: BOSSBS-2752R-A680

Descrizione: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2752R-A488)

Fornitore: Bioss

Codice articolo fornitore: BS-2752R-A488

Codice articolo locale: BOSSBS-2752R-A488

Descrizione: Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.

UOM: 1 * 100 µl

Promo

Codice catalogo: (HEID518-46100-00)

Fornitore: Heidolph Instruments GmbH & Co.KG

Codice articolo fornitore: 518-46100-00

Codice articolo locale: HEID518-46100-00

Descrizione: Hei-VAP industrial - performance plus package.

UOM: 1 * 1 pezzi

Promo

Fornitore: Lenz Laborglas GmbH & CO.KG

Descrizione: Borosilicate glass 3.3.

Fornitore: Lenz Laborglas GmbH & CO.KG

Descrizione: Borosilicate glass.

Fornitore: MOTIC

Descrizione: Accessory for microscopes, BD Plan achromatic objective BD PL 5×

Fornitore: Heidolph Instruments GmbH & Co.KG

Descrizione: G5, Vetro borosilicato, Coated, Capacità: 1000 ml

Codice catalogo: (201-0126)

Fornitore: Lenz Laborglas GmbH & CO.KG

Codice articolo fornitore: 06248815

Codice articolo locale: LENZ06248815

Descrizione: PTFE, white.

UOM: 1 * 1 pezzi

Promo

Codice catalogo: (531-3101)

Fornitore: Heidolph Instruments GmbH & Co.KG

Codice articolo fornitore: 15-300-003-20

Codice articolo locale: HEID15-300-003-20

Descrizione: Palloni di evaporazione, Vetro borosilicato 3.3, con flangia, Capacità: 6000 ml

UOM: 1 * 1 pezzi

Promo

Fornitore: THARMAC GmbH

Descrizione: Charcoal filter for fume hoods, Cellstain®

Fornitore: THARMAC GmbH

Descrizione: Open rotor JC105/12 with Quickchange 12-position, Per: Cyto centrifuges

Fornitore: Lenz Laborglas GmbH & CO.KG

Descrizione: DURAN®, borosilicate glass.