Hai cercato: Biosensis

Codice catalogo: (BSENM-1805-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1805-100

Codice articolo locale: BSENM-1805-100

Descrizione: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). Ref: uniprot.org

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENC-1812-50)

Fornitore: Biosensis

Codice articolo fornitore: C-1812-50

Codice articolo locale: BSENC-1812-50

Descrizione: Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells (By similarity). Ref: uniprot.org

UOM: 1 * 50 µl

Promo

Codice catalogo: (BSENM-026-50-AT)

Fornitore: Biosensis

Codice articolo fornitore: M-026-50-AT

Codice articolo locale: BSENM-026-50-AT

Descrizione: Monoclonal antibody MC192 against the rat low affinity nerve growth factor receptor (p75NTR) is derived from the fusion of Sp2/0-Ag 14 myeloma cells with mouse immune splenocytes. MC192 monoclonal antibody was originally generated by Chandlers et al. p75NTR was originally discovered as a low affinity nerve growth factor receptor. Later it was found that it was the receptor for all neurotrophins. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. MC192 has a potential use as the ligand for gene delivery into p75NTR-expressing rat cells via a receptor-mediated mechanism.
This antibody reacts with rat only. Does not react with mouse or human NGFR

UOM: 1 * 50 µG

Promo

Codice catalogo: (BSENM-1836-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1836-100

Codice articolo locale: BSENM-1836-100

Descrizione: The protein named TrkB (also named Neurotrophic tyrosine kinase receptor type 2 (NTRK2), GP145-TrkB or Tropomyosin-related kinase B is a receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems and is important in the regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. TrkB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. TrkB is the primary receptor for BDNF (brain-derived neurotrophic factor. TrkB also binds NT4 and NT3 but less efficiently. (Reference: www.uniprot.org).

Applications: Flow Cytometry (5-10 ug/mL): Tested on human and rodent cell lines. Cell staining can be performed under native conditions on ice, or on fixed cells with up to 4% formaldehyde. Other applications have not been tested. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

UOM: 1 * 100 µG

Promo

Fornitore: Biosensis

Descrizione: Mouse NGF (2.5S) was isolated from mouse submaxillary glands by method of Mobley et al (1976) and is a form of beta-NGF that has identical biological properties. NGF is known to regulate the survival and development of certain sympathetic and sensory neurons. It is a dimer with 2 identical polypeptide chains and dimeric molecular weight of approximately 26,500 Da. Isolation and purification of NGF from mouse submaxillary glands yields preparations of NGF (2.5S) with identical biological activity but with cleavages at the amino terminus (with the loss of 8 amino acids) and/or at the carboxy-terminus (with the loss of arginine). These preparations are named 2.5 NGF.

Certificati

Codice catalogo: (BSENR-1808-100)

Fornitore: Biosensis

Codice articolo fornitore: R-1808-100

Codice articolo locale: BSENR-1808-100

Descrizione: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. Ref: uniprot.org. This antibody recognizes laminin isotypes alpha-1 (440 kDa), beta-1 (220 kDa) and gamma-1 (220 kDa). It also binds laminin binding protein at 120 kDa which always co-expresses with laminin.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENM-1818-100)

Fornitore: Biosensis

Codice articolo fornitore: M-1818-100

Codice articolo locale: BSENM-1818-100

Descrizione: NGF receptor antibody clone 8J2 was developed specifically as a replacement for clone MLR2, which is no longer available anywhere for commercial use. Antibody reactivity for clone 8J2 has been validated for human, mouse and rat extracellular domain of p75NTR. Clone 8J2 has been demonstrated to perform equivalent to or better than MLR2 antibody in all testing.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENS-1754-500)

Fornitore: Biosensis

Codice articolo fornitore: S-1754-500

Codice articolo locale: BSENS-1754-500

Descrizione: Sheep serum from non-immunised animals was purified by protein G affinity chromatography. This sheep IgG fraction can be used as negative control antibody for various immunological techniques where sheep primary antibodies are used.

UOM: 1 * 500 µG

Promo

Codice catalogo: (BSENR-1803-100)

Fornitore: Biosensis

Codice articolo fornitore: R-1803-100

Codice articolo locale: BSENR-1803-100

Descrizione: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Ref: uniprot.org

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENR-1810-100)

Fornitore: Biosensis

Codice articolo fornitore: R-1810-100

Codice articolo locale: BSENR-1810-100

Descrizione: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). Ref: uniprot.org

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENR-1550-100)

Fornitore: Biosensis

Codice articolo fornitore: R-1550-100

Codice articolo locale: BSENR-1550-100

Descrizione: The Endothelin B receptor is a multi-pass membrane protein that belongs to the G-protein coupled receptor 1 family. It acts as a non-specific receptor for endothelin 1, 2, and 3.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENR-1571-100)

Fornitore: Biosensis

Codice articolo fornitore: R-1571-100

Codice articolo locale: BSENR-1571-100

Descrizione: Protein painting of fourth (Pof) is a probable RNA-binding protein that binds to the fourth chromosome and may bind a RNA that spreads the fourth chromosome (Ref: Swissprot).

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENS-052-500)

Fornitore: Biosensis

Codice articolo fornitore: S-052-500

Codice articolo locale: BSENS-052-500

Descrizione: FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons. SUBUNIT: Homodimer, associated by noncovalent forces. SUBCELLULAR LOCATION: Secreted protein. SIMILARITY: Belongs to the NGF-beta family.

UOM: 1 * 500 µG

Promo

Codice catalogo: (BSENR-1595-100)

Fornitore: Biosensis

Codice articolo fornitore: R-1595-100

Codice articolo locale: BSENR-1595-100

Descrizione: Peroxiredoxin-5 has a role in intracellular redox signaling.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BSENS-073-100)

Fornitore: Biosensis

Codice articolo fornitore: S-073-100

Codice articolo locale: BSENS-073-100

Descrizione: FUNCTION: Involved in redox regulation of the cell. Can reduce hydrogen peroxide and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. SUBUNIT: Homotetramer. May interact with HTR2A. SUBCELLULAR LOCATION: Cytoplasm. Lysosome. Also found in lung secretory organelles. MISCELLANEOUS: The active site is the redox-active Cys-47 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin . MISCELLANEOUS: Irreversibly inactivated by overoxidation of Cys-47 (to Cys-SO(3)H) upon oxidative stress. SIMILARITY: Belongs to the ahpC/TSA family. Rehydrin subfamily.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BSENR-1331-100)

Fornitore: Biosensis

Codice articolo fornitore: R-1331-100

Codice articolo locale: BSENR-1331-100

Descrizione: APPL1 (adaptor protein containing PH domain, PTB domain and leucine zipper motif 1) mediates adiponectin signaling in various types of cells. APPL1 is also thought to have a role in insulin signaling.

UOM: 1 * 100 µl

Promo