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Codice catalogo: (USBIS1013-29E1)

Fornitore: US Biological

Codice articolo fornitore: S1013-29E1

Codice articolo locale: USBIS1013-29E1

Descrizione: Anti-SHP 2 Rabbit Polyclonal Antibody

UOM: 1 * 10 pezzi

Promo

Codice catalogo: (BWRLBS1322)

Fornitore: Bioworld Technology

Codice articolo fornitore: BS1322

Codice articolo locale: BWRLBS1322

Descrizione: Synthetic peptide, corresponding to amino acids 500-550 of Human SHP-2.

UOM: 1 * 100 µG

Promo

Codice catalogo: (USBIS1013-29F1)

Fornitore: US Biological

Codice articolo fornitore: S1013-29F1

Codice articolo locale: USBIS1013-29F1

Descrizione: Anti-SHP 2 Rabbit Polyclonal Antibody

UOM: 1 * 10 pezzi

Promo

Codice catalogo: (BWRLBS4170)

Fornitore: Bioworld Technology

Codice articolo fornitore: BS4170

Codice articolo locale: BWRLBS4170

Descrizione: Synthetic phosphopeptide derived from human SHP-2 around the phosphorylation site of Tyrosine 542.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BWRLBS1705)

Fornitore: Bioworld Technology

Codice articolo fornitore: BS1705

Codice articolo locale: BWRLBS1705

Descrizione: Synthetic peptide, corresponding to amino acids 550-600 of Human SHP-2.

UOM: 1 * 100 µG

Promo

Codice catalogo: (USBI145110)

Fornitore: US Biological

Codice articolo fornitore: 145110

Codice articolo locale: USBI145110

Descrizione: Anti-PTPN11/SHP-2 Rabbit Polyclonal Antibody

UOM: 1 * 100 µG

Promo

Codice catalogo: (BWRLBS4169)

Fornitore: Bioworld Technology

Codice articolo fornitore: BS4169

Codice articolo locale: BWRLBS4169

Descrizione: Synthetic phosphopeptide derived from human SHP-1 around the phosphorylation site of Tyrosine 536.

UOM: 1 * 100 µG

Promo

Codice catalogo: (BWRLBS6827)

Fornitore: Bioworld Technology

Codice articolo fornitore: BS6827

Codice articolo locale: BWRLBS6827

Descrizione: Synthetic peptide, corresponding to amino acids 550-600 of Human EphA2.

UOM: 1 * 100 µG

Promo

Codice catalogo: (USBIN6889-91H)

Fornitore: US Biological

Codice articolo fornitore: N6889-91H

Codice articolo locale: USBIN6889-91H

Descrizione: Anti-Nuclear Receptor SHP Rat Monoclonal Antibody [clone: 6D624]

UOM: 1 * 50 µG

Promo

Codice catalogo: (BOSSBS-13184R-A750)

Fornitore: Bioss

Codice articolo fornitore: BS-13184R-A750

Codice articolo locale: BOSSBS-13184R-A750

Descrizione: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2767R-FITC)

Fornitore: Bioss

Codice articolo fornitore: BS-2767R-FITC

Codice articolo locale: BOSSBS-2767R-FITC

Descrizione: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-13184R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-13184R-A350

Codice articolo locale: BOSSBS-13184R-A350

Descrizione: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2767R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-2767R-HRP

Codice articolo locale: BOSSBS-2767R-HRP

Descrizione: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-2767R)

Fornitore: Bioss

Codice articolo fornitore: BS-2767R

Codice articolo locale: BOSSBS-2767R

Descrizione: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-3150R)

Fornitore: Bioss

Codice articolo fornitore: BS-3150R

Codice articolo locale: BOSSBS-3150R

Descrizione: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

UOM: 1 * 100 µl

Promo

Fornitore: Biotium

Descrizione: Recognizes a 67 kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.