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Image Unavailable-BOSSBS-11066R-A555

Anti-DOK6 Rabbit Polyclonal Antibody (Alexa Fluor® 555)

Codice catalogo: (BOSSBS-11066R-A555)
Fornitore: Bioss
Codice articolo fornitore: BS-11066R-A555
Codice articolo locale: BOSSBS-11066R-A555
Descrizione: The downstream of kinase family (Dok-1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11066R-A350

Anti-DOK6 Rabbit Polyclonal Antibody (Alexa Fluor® 350)

Codice catalogo: (BOSSBS-11066R-A350)
Fornitore: Bioss
Codice articolo fornitore: BS-11066R-A350
Codice articolo locale: BOSSBS-11066R-A350
Descrizione: The downstream of kinase family (Dok-1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11066R-FITC

Anti-DOK6 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Codice catalogo: (BOSSBS-11066R-FITC)
Fornitore: Bioss
Codice articolo fornitore: BS-11066R-FITC
Codice articolo locale: BOSSBS-11066R-FITC
Descrizione: The downstream of kinase family (Dok-1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11066R-A647

Anti-DOK6 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-11066R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-11066R-A647
Codice articolo locale: BOSSBS-11066R-A647
Descrizione: The downstream of kinase family (Dok-1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11066R-CY3

Anti-DOK6 Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-11066R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-11066R-CY3
Codice articolo locale: BOSSBS-11066R-CY3
Descrizione: The downstream of kinase family (Dok-1-7) are members of a class of “docking” proteins that include the tyrosine kinase substrates IRS-1 and Cas, which contain multiple tyrosine residues and putative SH2 binding sites. Dok-4, Dok-5 and Dok-6 are more similar to each other than to the other Dok family members, and may constitute a subfamily of the DOK genes. Dok-5 is a tyrosine kinase substrate that enhances c-Ret-dependent activation of mitogen-activated protein kinase (MAPK). Dok-5 transcript is abundant in muscle and increases during T cell activation. Dok-5 protein undergoes tyrosine phosphorylation in response to insulin and insulin-like growth factor-1. Dok-6 is highly expressed in the developing central nervous system. It associates with Ret to transduce Ret-mediated processes such as axonal projection.
UOM: 1 * 100 µl
Image Unavailable-PERCL1202057

Polystyrene Test Film - MIR

Codice catalogo: (PERCL1202057)
Fornitore: PerkinElmer
Codice articolo fornitore: L1202057
Codice articolo locale: PERCL1202057
Descrizione: This test film is an easy-to-use standard to check frequency, accuracy and any changes.
UOM: 1 * 1 pezzi
Product Image-BOCH10021

Wire baskets, square and rectangular

Fornitore: BOCHEM
Descrizione: These stainless steel baskets are designed for transporting, storing, cleaning and sterilising laboratory utensils.

Product Image-903-0406

Accessori per il sistema HPLC VWR® Hitachi Chromaster

Fornitore: VWR Collection
Descrizione: Rack per campioni Chromaster HPLC per 120 fiale per campioni da 1,5 ml. Fornito di serie con autocampionatori Chromaster 5210 e 5260

Image Unavailable-BOSSBS-11826R-CY3

Anti-DOK4 Rabbit Polyclonal Antibody (Cy3®)

Codice catalogo: (BOSSBS-11826R-CY3)
Fornitore: Bioss
Codice articolo fornitore: BS-11826R-CY3
Codice articolo locale: BOSSBS-11826R-CY3
Descrizione: The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12867R-HRP

Anti-NR1H4 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Codice catalogo: (BOSSBS-12867R-HRP)
Fornitore: Bioss
Codice articolo fornitore: BS-12867R-HRP
Codice articolo locale: BOSSBS-12867R-HRP
Descrizione: The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-12867R-A488

Anti-NR1H4 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-12867R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-12867R-A488
Codice articolo locale: BOSSBS-12867R-A488
Descrizione: The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and binds DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, and several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed “orphan receptors” because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11826R-A488

Anti-DOK4 Rabbit Polyclonal Antibody (Alexa Fluor® 488)

Codice catalogo: (BOSSBS-11826R-A488)
Fornitore: Bioss
Codice articolo fornitore: BS-11826R-A488
Codice articolo locale: BOSSBS-11826R-A488
Descrizione: The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-11826R-A647

Anti-DOK4 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Codice catalogo: (BOSSBS-11826R-A647)
Fornitore: Bioss
Codice articolo fornitore: BS-11826R-A647
Codice articolo locale: BOSSBS-11826R-A647
Descrizione: The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.
UOM: 1 * 100 µl
Image Unavailable-BOSSBS-7068R

Anti-FOXO1 Rabbit Polyclonal Antibody

Codice catalogo: (BOSSBS-7068R)
Fornitore: Bioss
Codice articolo fornitore: BS-7068R
Codice articolo locale: BOSSBS-7068R
Descrizione: FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined. FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia. FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
UOM: 1 * 100 µl
Product Image-216-0167

VWR®, vasetti, bocca larga, con tappo a vite

Codice catalogo: (216-0167)
Fornitore: VWR Collection
Codice articolo locale: VWRI216-0167
Descrizione: PTFE, a pareti rinforzate.
UOM: 1 * 1 pezzi
Product Image-216-2399

VWR®, Solid Euro Containers

Fornitore: VWR Collection
Descrizione: These plastic stackable Euro containers are ideal for simple storage solutions as well as highly automated systems. Made from strong plastic these containers are ideal for transporting goods and food safely. They are very stable when loaded due to reinforced frame and corner construction.

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La disponibilità per questo articolo è limitata, ma potrebbe essere disponibile in un magazzino vicino a voi. Si prega di assicurarsi che si è effettuato l'accesso al sito, in modo che ledisponibilità possano essere visualizzati. Se il call è ancora visualizzato e hai bisogno di assistenza, si prega di telefonare a 1-800-932 - 5000.
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