Hai cercato: 8-Bromoadenosine+3\',5\'-cyclic+Monophosphothioate,+Rp-Isomer+sod

Fornitore: ENZO LIFE SCIENCES AG

Descrizione: Inhibitor of cAMP-dependent protein kinase (PKA), preferentially binding to type I PKA. Lipophilic analog of Rp-cAMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic and membrane permeant as compared to Rp-cAMPS or 8-Br-cAMP.

New Product

Codice catalogo: (ENZOALX480025M001)

Fornitore: ENZO LIFE SCIENCES AG

Codice articolo fornitore: ALX480025M001

Codice articolo locale: ENZOALX480025M001

Descrizione: PKA activator.

UOM: 1 * 1 mg

New Product Promo

Codice catalogo: (ENZOALX480085M001)

Fornitore: ENZO LIFE SCIENCES AG

Codice articolo fornitore: ALX480085M001

Codice articolo locale: ENZOALX480085M001

Descrizione: Competitive inhibitor of cyclic AMP-dependent protein kinase I and II.Metabolic stability towards mammalian cyclic nucleotide- responsive phosphodiesterases.
Discriminates between protein kinase A (antagonist) and some other cyclic AMP receptors, e.g. channels or CAP 3 (agonist).Membrane-permeant for several systems (for improved permeability more lipophilic analogues e.g. Rp-8-Br-cAMPS are recommended).

UOM: 1 * 1 mg

New Product Promo

Codice catalogo: (ENZOALX480072M001)

Fornitore: ENZO LIFE SCIENCES AG

Codice articolo fornitore: ALX480072M001

Codice articolo locale: ENZOALX480072M001

Descrizione: Inhibitor of cGMP-dependent protein kinase (PKG) 1α (cGMP antagonist). Resistant against mammalian cyclic nucleotid-dependent phosphodiesterases. No metabolic side effects. Low membrane permeability.

UOM: 1 * 1 mg

New Product Promo

Codice catalogo: (ENZOBMLCN2060001)

Fornitore: ENZO LIFE SCIENCES AG

Codice articolo fornitore: BMLCN2060001

Codice articolo locale: ENZOBMLCN2060001

Descrizione: A cell-permeable cGMP antagonist which is resistant to hydrolysis by cyclic nucleotide phosphodiesterases (Ki=0.5 µM). No metabolic side effects. Significantly more lipophilic and membrane permeant as compared to Rp-cGMPS or Rp-8-Br-cGMPS

UOM: 1 * 1 mg

New Product Promo

Fornitore: ENZO LIFE SCIENCES AG

Descrizione: Potent selective inhibitor of cGMP-dependent protein kinase 1α, 1β and type II. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases, no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to Rp-cGMPS or Rp-8-Br-cGMPS.

New Product

Fornitore: ENZO LIFE SCIENCES AG

Descrizione: PKA activator.

New Product

Fornitore: TCI EUROPE

Descrizione: Tetraethylenepentamine (mixture of branched chain isomers and cyclic compounds)

Fornitore: TCI EUROPE

Descrizione: 4-Methyl-1,3,2-dioxathiolane-2-oxide (mixture of isomers) ≥98.0% (by GC)

Codice catalogo: (ENZOBMLCN1350001)

Fornitore: ENZO LIFE SCIENCES AG

Codice articolo fornitore: BMLCN1350001

Codice articolo locale: ENZOBMLCN1350001

Descrizione: Rp-cAMPS is a potent and specific competitive inhibitor of the activation of cAMP-dependent protein kinases by cAMP (IC50=4.9 µM) . Its cell permeability and complete resistance to cyclic nucleotide phosphodiesterases make it a unique tool for studying cAMP-dependent signaling. Significantly more lipophilc as compared to cAMP and thus membrane permeable in many biological systems. This product is not sterile.

UOM: 1 * 1 mg

New Product Promo

Fornitore: Apollo Scientific

Descrizione: 4-Methyl-1,3,2-dioxathiolane-2-oxide (mixture of isomers) 98%

Codice catalogo: (ENZOBMLCN2160500)

Fornitore: ENZO LIFE SCIENCES AG

Codice articolo fornitore: BMLCN2160500

Codice articolo locale: ENZOBMLCN2160500

Descrizione: Cell-permeable, phosphodiesterase-resistant cGMP antagonist. Reversed NO stimulation of random migration in rabbit neutrophils. Used at 30µM to cometively inhibit 8-Br-cGMP relaxation of rabbit aortas. The product is not sterile. Resistant to nucleotide-dependent phosphodiesterases; no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to cyclic GMP or Rp-cGMPS.

UOM: 1 * 500 µG

New Product Promo

Fornitore: Merck

Descrizione: Le colonne Purospher® STAR RP-8 con endcapping, come le colonne Purospher® STAR RP-18 con endcapping, sono basate su silice ad elevata purezza e su una copertura quasi completa della superficie. Perciò, le colonne Purospher® STAR RP-8 forniscono un’eccellente simmetria dei picchi per composti acidi, basici oltre che chelanti, massima efficienza della colonna in termini di numero di piastre teoriche ed eccezionale stabilità con pH da 1,5 a 10,5. Inoltre, le colonne Purospher® STAR RP-8 con endcapping offrono una vasta applicabilità. Poiché il sorbente è meno idrofobo rispetto al tipo Purospher® STAR RP-18 con endcapping, normalmente gli analiti eluiscono più rapidamente nella fase C8. Purospher® STAR RP-8 con endcapping offre una selettività migliorata per isomeri posizionali e forme dei picchi simmetriche per composti fortemente basici e meno idrofobi.

MSDS

Codice catalogo: (BOSSBS-11332R-A350)

Fornitore: Bioss

Codice articolo fornitore: BS-11332R-A350

Codice articolo locale: BOSSBS-11332R-A350

Descrizione: Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11332R-HRP)

Fornitore: Bioss

Codice articolo fornitore: BS-11332R-HRP

Codice articolo locale: BOSSBS-11332R-HRP

Descrizione: Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

UOM: 1 * 100 µl

Promo

Codice catalogo: (BOSSBS-11332R-CY7)

Fornitore: Bioss

Codice articolo fornitore: BS-11332R-CY7

Codice articolo locale: BOSSBS-11332R-CY7

Descrizione: Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.

UOM: 1 * 100 µl

Promo