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Rapamycin ≥98% (by HPLC)

Fornitore: ENZO LIFE SCIENCES AG

Synonyms: (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone

BMLA2750005 BMLA2750025
ENZOBMLA2750005EA 118.8 EUR
ENZOBMLA2750005 ENZOBMLA2750025
Rapamycin ≥98% (by HPLC)
Rapamycin

Macrocyclic-triene antibiotic possessing potent immunosuppressant activity. It forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12 target). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin induces inhibition of p70s6k, p33cdk2 and p34cdc2. Selectively blocks signaling leading to the activation of p70/85 S6 kinase. Enhances apoptosis. Activator of autophagy both in vitro and in vivo.


  • Off-white or yellow solid


Soluble in chloroform, DMSO (25 mg/mL) or methanol


Confezione: Shipping temperature: Ambient

Formula: C₅₁H₇₉NO₁₃
Peso molecolare: 914,19 g/mol
Temperatura di stoccaggio: Congelamento
MDL Number: MFCD00867594
CAS Number: 53123-88-9

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