SB 225002 ≥98% (by HPLC)
Fornitore: ENZO LIFE SCIENCES AG
Synonyms:
SB225002, 1-(2-Bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
Chemokine receptor ligand
Potent and selective antagonist of CXCR2 chemokine receptor (IC50=22nM). >150-fold more selective over CXCR1 receptor. Inhibits IL-8- (IC50=8nM) and GROα-mediated (IC50=10nM) calcium mobilisation. Prevents IL-8-induced neutrophil migration. Inhibits HIV replication in lymphocytes and macrophages.
Formula:
C₁₃H₁₀BrN₃O₄ Peso molecolare: 352,10 g/mol |
MDL Number:
MFCD00954637 CAS Number: 182498-32-4 |
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