4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinoline ≥97% (by 1H-NMR)
Fornitore: ENZO LIFE SCIENCES AG
Synonyms:
LY364947, 4-(3-(Pyridin-2-yl)-1H-pyrazol-4-yl)quinoline
Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=51nM). Displays ~15-fold greater selectivity over p38α MAPK (IC50=740nM). Inhibits TGF-β-dependent cellular growth (IC50=89nM in NIH 3T3 mouse fibroblasts) and transcription activation (IC50=47nM in mink lung cells). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay.
Yellow to brown solid.
Soluble in DMSO or methanol.
Formula:
C₁₇H₁₂N₄ Peso molecolare: 272,31 g/mol Temperatura di stoccaggio: Congelamento |
MDL Number:
MFCD00800758 CAS Number: 396129-53-6 |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...