SC-236 ≥95% (by HPLC)
Fornitore: ENZO LIFE SCIENCES AG
Synonyms:
4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulphonamide, 4-(5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulphonamide
Highly selective and potent inhibitor of cyclooxygenase-2 (IC50=10nM for COX-2 versus IC50=17.8µM for COX-1) with antitumor properties. Exhibits longer half-life time and reduced gastric toxicity in fasting rat model. Has antitumor properties and has been shown to induce apoptosis and bFGF and VEGF-driven angiogenesis. Potent antimetastatic activity against both spontaneous metastases arising following primary tumour excision and experimental metastases.
- COX inhibitor
White to off-white crystalline powder.
Soluble in DMSO.
Formula:
C₁₆H₁₁ClF₃N₃O₂S Peso molecolare: 401,8 g/mol Temperatura di stoccaggio: Congelamento |
MDL Number:
MFCD00941297 CAS Number: 170569-86-5 |
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