ENMD-1068
Fornitore: ENZO LIFE SCIENCES
Proteinase-activated receptor ligand
Selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-α and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaolin-injected mouse model.
Formula:
C₁₅H₂₉N₃O₂·HCl Peso molecolare: 319.87 g/mol |
CAS Number:
789488-77-3 |
|
Learn more

About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...