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ENMD-1068

Fornitore: ENZO LIFE SCIENCES

BMLN1100005 BMLN1100025
ENZOBMLN1100005EA 131 EUR
ENZOBMLN1100005 ENZOBMLN1100025
ENMD-1068
ENMD-1068

Proteinase-activated receptor ligand


Selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-α and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaolin-injected mouse model.

Formula: C₁₅H₂₉N₃O₂·HCl
Peso molecolare: 319.87 g/mol
CAS Number: 789488-77-3
https://digitalassets.avantorsciences.com/adaptivemedia/rendition?id=f2af71c2f9cf2f6cb669c18f9e410b10cc043d61&vid=5263fcccccd4937a35428b8737c66790e2008043&prid=web&clid=SAPDAM

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