D,L-threo-PDMP hydrochloride ≥98% (by TLC)
Fornitore: ENZO LIFE SCIENCES AG
Synonyms:
D,L-threo-PDMP hydrochloride
Blocks glucosylation of ceramide by inhibiting UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthetase). Inhibits the expression of cell surface glycolipid antigens and inhibits the growth of cultured rabbit skin fibroblasts. Possesses antitumor activity and inhibits Lewis lung carcinoma cell metastasis in vitro. Useful tool for studying the effects of cellular glycosphingolipid depletion. Enhances the apoptotic response to ionizing radiation by enhancing the ceramide signal.
- Glucosylceramide synthetase inhibitor
White to off-white solid.
25mg/ml soluble in 100% ethanol, DMSO or water (50°C, vortex or sonicate).
Formula:
C₂₃H₃₈N₂O₃·HCl Peso molecolare: 390,6·36,5 g/mol Temperatura di stoccaggio: Congelamento |
MDL Number:
MFCD00236490 CAS Number: 80938-69-8 |
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