JZL-184 ≥98% (by TLC)
Fornitore: ENZO LIFE SCIENCES AG
Synonyms:
JZL184, 4-Nitrophenyl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate, 4-Nitrophenyl-4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate
Potent, selective and irreversible inhibitor of MAG lipase (IC50=8nM vs 4µM for FAAH). JZL-184-treated mice displayed a number of CB1-dependent behavioral effects including analgesia, hypothermia and hypomotility as well as increased levels of 2-arachidonoylglycerol in the brain ( approx. 8-fold, with no effect on anandamide levels). JZL-184 produces a rapid and sustained blockade of brain 2-AG hydrolase activity in mice. It blocks neuropathic pain and enhances retrograde endocannabinoid signaling.
- Monoacylglycerol lipase inhibitor
Off-white solid.
Soluble in DMSO (10mg/ml).
Formula:
C₂₇H₂₄N₂O₉ Peso molecolare: 520,5 g/mol Temperatura di stoccaggio: Ambiente |
MDL Number:
MFCD11976911 CAS Number: 1101854-58-3 |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...