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MK-886 ≥98% (by HPLC)

Fornitore: ENZO LIFE SCIENCES AG

Synonyms: 3-(3-(tert-Butylthio)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl)-2,2-dimethylpropanoic acid, L-663,536, 3-[1-(p-Chlorobenzyl)-5-(isopropyl)-3-t-butylthioindol-2-yl]-2,2-dimethylpropanoic acid Na

BMLEI2660005 BMLEI2660025
ENZOBMLEI2660005EA 110 EUR
ENZOBMLEI2660005 ENZOBMLEI2660025
MK-886 ≥98% (by HPLC)
MK-886

Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.


  • FLAP inhibitor


White solid.


Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).

Formula: C₂₇H₃₃ClNO₂S·Na
Peso molecolare: 494,0 g/mol
Temperatura di stoccaggio: Ambiente
MDL Number: MFCD00876710
CAS Number: 118414-82-7
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