Mdivi -1 ≥97% (by HPLC)
Fornitore: ENZO LIFE SCIENCES AG
Synonyms:
Mdivi-1, 3-(2,4-Dichloro-5-methoxyphenyl)-2-mercaptoquinazolin-4(3H)-one, 3-(2,4-Dichloro-5-methoxyphenyl)-2-thioxo-2,3-dihydro-4(1H)-quinazolinone
Mdivi-1 is a selective inhibitor of mitochondrial division in yeast and mammalian cells which acts via inhibiting the mitochondrial division dynamin. In cells, Mdivi-1 inhibits apoptosis by inhibiting mitochondrial outer membrane permeabilization. Mdivi-1 causes the rapid (50= ~10µM. In yeast, time-lapse fluorescence microscopy revealed no detectable mitochondrial division after treatment with Mdivi-1. It inhibits Dnm1 GTPase activity in a dose dependent manner with an estimated IC50 of 1-10µM but is not a general inhibitor of GTPases.
- Inhibitor of mitochondrial division
White solid.
Soluble in DMSO (25mg/ml).
Formula:
C₁₅H₁₀Cl₂N₂O₂S Peso molecolare: 353,2 g/mol Temperatura di stoccaggio: Congelamento |
MDL Number:
MFCD00974506 CAS Number: 338967-87-6 |
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