XAV939 ≥98% (by TLC)
Fornitore: ENZO LIFE SCIENCES AG
Synonyms:
2-(4-(Trifluoromethyl)phenyl)-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one, XAV-939
PARP5a inhibitor
Potent inhibitor of Tankyrase 1 (IC50=11nM) and Tankyrase 2 (IC50=4nM). Inhibition of tankyrase promotes stabilization of axin resulting in β-catenin degradation and Wnt signalling disruption. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.
Formula:
C₁₄H₁₁F₃N₂OS Peso molecolare: 312,3102 g/mol |
MDL Number:
MFCD16879017 CAS Number: 284028-89-3 |
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