H-89 dihydrochloride ≥99% (by TLC)
Fornitore: ENZO LIFE SCIENCES AG
Protein kinase inhibitor
Cell permeable potent and selective inhibitor of cAMP- and cGMP-dependent protein kinases (PKA, Ki=48nM, and PKG) and protein kinase Cµ (PKCµ). In contrast, most other protein kinase C (PKC) isotypes are much more weakly inhibited. Also inhibits Ca2+/calmodulin-dependent protein kinase II, casein kinase I and myosin light chain kinase. Induces apoptosis. Concentration range for cultured cells 30-100μM: osteoblastic cells, renal proximal tubule cells and Xenopus oocytes.
Formula:
C₂₀H₂₀BrN₃O₂S·2HCl |
CAS Number:
127243-85-0 |
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