SB216763 ≥98% (by TLC)
Fornitore: ENZO LIFE SCIENCES AG
Synonyms:
3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, SB-216763
Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model.
- GSK inhibitor
Orange solid
Soluble in DMSO (>25mg/ml).
Formula:
C₁₉H₁₂Cl₂N₂O₂ Peso molecolare: 371,2 g/mol Temperatura di stoccaggio: Ambiente |
MDL Number:
MFCD09753369 CAS Number: 280744-09-4 |
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