Butyrolactone I ≥99% (by TLC)
Fornitore: ENZO LIFE SCIENCES AG
CDK inhibitor
Cell permeable and selective inhibitor of the cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5. Inhibits cell cycle progression at the G1/S and G2/M transitions. G1/S and G2/M transitions, in W138 cells, were inhibited, concurrent with inhibition of the phosphorylations of, respectively, retinoblastoma protein and histone H1. It is an important tool for probing the cellular roles of CDKs. Blocks Fas-induced apoptosis. Displays antitumor activity.
Formula:
C₂₄H₂₄O₇ |
MDL Number:
MFCD03453074 CAS Number: 87414-49-1 |
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