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Gambogic amide ≥98% (by TLC)

Fornitore: ENZO LIFE SCIENCES AG
Pericolo

BMLN1590001 BMLN1590005
ENZOBMLN1590001EA 133.1 EUR
ENZOBMLN1590001 ENZOBMLN1590005
Gambogic amide ≥98% (by TLC)
Gambogic amide

TrkA ligand


A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM.


Soluble in DMSO (20 mg/ml) or ethanol (20 mg/ml).

Formula: C₃₈H₄₅NO₇
Punto di fusione: 74…76 °C
Temperatura di stoccaggio: Ambiente
CAS Number: 286935-60-2
https://digitalassets.avantorsciences.com/adaptivemedia/rendition?id=ede2973f64c24278e3fee48bc4f9bcbecc0b0af7&vid=0bf45e22b3a568f469bd8d5855fb9568db7bdbd8&prid=web&clid=SAPDAM

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Risultati del test di specificazione

Purity ≥98% (TLC)
Appearance Yellow-orange solid
Melting Point 74 - 76°C

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