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Haloenol lactone suicide substrate ≥98% (by TLC)

Fornitore: ENZO LIFE SCIENCES

Synonyms: HELSS

BMLST3400005 BMLST3400025
ENZOBMLST3400005EA 161 EUR
ENZOBMLST3400005 ENZOBMLST3400025
Haloenol lactone suicide substrate ≥98% (by TLC)
Haloenol lactone suicide substrate

HELSS is a potent, irreversible, mechanism-based inhibitor of Ca2+-independent PLA2 (70% inhibition at 100 nM). It possesses a 1000-fold selectivity for Ca2+-independent PLA2 vs. Ca2+-dependent PLA2 . It has been used to identify the PLA2 involved in the release of arachidonate induced by vasopressin stimulation of A-10 smooth muscle cells (IC50=1 µM). It has also been shown to inhibit the Mg2+-dependent phophatidate phosphohydrolase from P388D1 macrophages (IC50~8 µM).


  • Phospholipase inhibitor


White solid.


Soluble in DMSO (25mg/ml).

Formula: C₁₆H₁₃BrO₂
Peso molecolare: 317,2 g/mol
Punto di fusione: 104…106 °C
Temperatura di stoccaggio: Congelamento
MDL Number: MFCD00270871
CAS Number: 88070-98-8
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