Fasudil dihydrochloride ≥98% (by TLC)
Fornitore: ENZO LIFE SCIENCES AG
Synonyms:
1-(5-Isoquinolinesulphonyl)homopiperazine dihydrochloride salt, HA-1077 dihydrochloride salt
Inhibits Rho kinase (ROCK; Ki=0.33μM). Selective protein kinase A and G inhibitor (both Ki’s = 1.6μM). Inhibits agonist-induced activation of NADPH oxidase in human neutrophils (IC50=15μM). Inhibitor of myosin light chain kinase and Ca2+/calmodulin-dependent protein kinase II. Inhibits translocation of PKCβI, PKCβII and PKCζ. Cell permeable Ca2+ antagonist with antivasospastic properties.
- Rho kinase (ROCK) inhibitor
White to off-white solid.
Soluble in water (>20mg/ml), methanol or DMSO.
Formula:
C₁₄H₁₇N₃O₂S·2HCl Peso molecolare: 364,29 g/mol Temperatura di stoccaggio: Congelamento |
MDL Number:
MFCD00153805 CAS Number: 203911-27-7 |
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