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Troglitazone ≥98% (by TLC)

Fornitore: ENZO LIFE SCIENCES AG

Synonyms: 5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)thiazolidine-2,4-dione

BMLGR2100005 BMLGR2100025
ENZOBMLGR2100005EA 134.2 EUR
ENZOBMLGR2100005 ENZOBMLGR2100025
Troglitazone ≥98% (by TLC)
Troglitazone

PPAR ligand


Antidiabetic thiazolidinedione. Potent and selective PPARγ ligand. Binds to the PPARγ ligand-binding domain and recruits ligand-specific transcriptional coactivators at 1µM. In skeletal muscle and adipocyte cell cultures, the EC50 of troglitazone is about 10µM. Displaces [125I]SB-236636 with an IC50=7.9 µM. Stimulates adipogenesis and decreases osteoblastogenesis in human mesenchymal stem cells. Induces apoptosis in human vascular smooth muscle cells and inhibits the growth of a variety of human cancer cells including lung, bladder and myeloid leukemia cells.


Synthetic.

Formula: C₂₄H₂₇NO₅S
Peso molecolare: 441,5 g/mol
MDL Number: MFCD00878416
CAS Number: 97322-87-7
https://digitalassets.avantorsciences.com/adaptivemedia/rendition?id=10dcf0bfa8bcd161c397ed22b71d3b3e7a351c16&vid=0202869628fd830de451b310c4f15fdecb6885b8&prid=web&clid=SAPDAM

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