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Fumonisin B1 ≥98%

Fornitore: ENZO LIFE SCIENCES AG

BMLSL2200001 BMLSL2200005
ENZOBMLSL2200001EA 99 EUR
ENZOBMLSL2200001 ENZOBMLSL2200005
Fumonisin B1 ≥98%
Fumonisin B1

Ceramide synthase inhibitor


A fungal metabolite produced by Fusarium moniliforme. Mycotoxin. Inhibits sphinganine N-acyl-transferase(ceramide synthase)(IC50=0.1µM). Inhibits de novo sphingolipid biosynthesis (IC50=0.7µM for sphingomyelin labeling by [3H]sphinganine, cultured cerebellar neurons). Inhibits growth of axons in cultured hippocampal neurons by blocking glycosphingolipid synthesis. Induces DNA damage in the liver and cancer. Induces apoptosis. Activates Akt (protein kinase B; PKB), which leads to increased survival, inhibition of GSK-3β activity and post-translational stabilization of cyclin D1.

Formula: C₃₄H₅₉NO₁₅
Peso molecolare: 721,838 g/mol
MDL Number: MFCD00133349
CAS Number: 116355-83-0
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