Paxilline ≥97% (by HPLC)
Fornitore: ENZO LIFE SCIENCES
K+ channel blocker
Paxilline is an indole alkaloid isolated from Penicillium paxilli. It is a selective and reversible blocker of the smooth muscle high conductance Ca2+-activated K+ (maxi-K) channel (70% block at 10 nM). In neutrophils, Paxilline blockage of BKCa channels decreased the alkalinization of phagocytic vacuoles and inhibited the microbicidal process. Inhibitor of the cerebellar inositol 1,4,5-triphosphate (InsP(3)) receptor.
Formula:
C₂₇H₃₃NO₄ Peso molecolare: 435.564 g/mol |
MDL Number:
MFCD00083464 CAS Number: 57186-25-1 |
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