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Wortmannin ≥98% (by TLC)

Fornitore: ENZO LIFE SCIENCES AG

Synonyms: (1S,6bR,9aS,11R,11bR)-1-(Methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate

BMLST4150001 BMLST4150005
ENZOBMLST4150001EA 66 EUR
ENZOBMLST4150001 ENZOBMLST4150005
Wortmannin ≥98% (by TLC)
Wortmannin

PI3 kinase inhibitor


Potent and selective inhibitor of phosphatidyl-inositol 3-kinase. Active in purified preparations and cytosolic fractions(IC50 = 5nM) and is highly cell permeable. Inhibits fMLP induced PIP3 and superoxide anion production (IC50 = 50nM) in guinea pig neutrophils and blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Covalently binds to PI 3-kinase and is selective, inhibiting other kinases such as PI 4-kinase and myosin light chain kinase at concentrations 100-fold higher than that required for inhibition of PI 3-kinase. The half-life of wortmannin in culture media is quite short (8-13 minutes), care should be taken to account for this decomposition when planning experiments. Markedly potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau.

Formula: C₂₃H₂₄O₈
Peso molecolare: 428,44 g/mol
MDL Number: MFCD00133927
CAS Number: 19545-26-7

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