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Geldanamycin ≥95% (by HPLC)

Fornitore: ENZO LIFE SCIENCES

Synonyms: (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

BMLEI2800001 BMLEI2800005
ENZOBMLEI2800001EA 165 EUR
ENZOBMLEI2800001 ENZOBMLEI2800005
Geldanamycin ≥95% (by HPLC)
Geldanamycin

Potent antitumor antibiotic. Inhibitor of pp60src tyrosine kinase and of c-myc gene expression in murine lymphoblastoma cells. Inhibits the transforming activity of abl, erbB, fps, src, and yes.


  • Yellow solid


Binds specifically to heat shock protein 90 (HSP90) and to its endoplasmic reticulum homolog GP96 (GRP94). Capable of destabilizing several oncogene and proto-oncogene products. Potent inhibitor of the nuclear hormone receptor family. Protects against alpha-synuclein toxicity to dopaminergic neurons in Drosophila. Destabilizes mutant p53 protein from a number of breast, leukemic, and prostate cell lines. Inhibits basal and hypoxia-induced expression of c-Jun (IC50=75nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase (JNK) activity. Inhibits telomerase activity through inhibition of HSP90, a chaperone required for the assembly and activation of telomerase in human cells. Hsp90 inhibitors geldanamycin or 17-DMAG reduces the uptake of Chaperone Mediated Autophagy (CMA) substrates by isolated lysosomes. 10-fold more potent than herbimycin A.


Soluble in DMSO (10 mg/mL); insoluble in water


Confezione: Shipping temperature: Ambient

Formula: C₂₉H₄₀N₂O₉
Peso molecolare: 560.64 g/mol
Temperatura di stoccaggio: Congelamento
MDL Number: MFCD00274570
CAS Number: 30562-34-6
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