BI-605906 ≥98%
Fornitore: Cayman Chemical
Synonyms:
3-Amino-4-(1,1-difluoropropyl)-6-[4-(methylsulphonyl)-1-piperidinyl]thieno[2,3-b]pyridine-2-carboxamide
- An IKKβ inhibitor
An IKKβ inhibitor (IC50 = 380 nM); selective for IKKβ over insulin-like growth factor 1 (IGF1; IC50 = 7.6 μM) and over 100 kinases in a panel up to 10 μM; partially inhibits IL-1-stimulated activation of IKKε/TBK1 in vitro; inhibits TNF-α-dependent IkB degradation and expression of the proinflammatory cytokines IL-6, IL-1β, and CXCL1/2 without affecting lipogenic gene expression or glucose production in murine primary hepatocytes
Formula:
C₁₇H₂₂F₂N₄O₃S₂ Peso molecolare: 432,51 g/mol Temperatura di stoccaggio: Congelamento |
CAS Number:
960293-88-3 |
Risultati del test di specificazione
Formulation | A crystalline solid |
Purity | ≥98% |
Stability | ≥ 2 years |
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