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Purvalanol A ≥98%, crystalline solid

Fornitore: Cayman Chemical

Synonyms: 6-[(3-Chloro)anilino]-2(1R)-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine, (R)-2-((6-((3-Chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)-3-methylbutan-1-ol

14579-10 14579-50 14579-5 14579-100
CAYM14579-10EA 133 EUR
CAYM14579-10 CAYM14579-50 CAYM14579-5 CAYM14579-100
Purvalanol A ≥98%, crystalline solid
Purvalanol A

Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively.


Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death. At 10 μM, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT-29 and SW48 human colon cancer cells.


Attenzione: Not for human or veterinary use.

Formula: C₁₉H₂₅N₆OCl
Peso molecolare: 388,9 g/mol
Temperatura di stoccaggio: Congelamento
MDL Number: MFCD02179211
CAS Number: 212844-53-6

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Purity ≥98%

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