EPZ-5676 (Pinometostat) ≥98%
Fornitore: Cayman Chemical
Synonyms:
(2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(((cis-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol, Pinometostat
EPZ5676 is a highly potent aminonucleoside inhibitor of DOT1 l histone methyltransferase activity (Ki = 80 pM) that demonstrates 37000-fold selectivity over other methyltransferases.
It can selectively inhibit the proliferation of acute leukemia cell lines bearing MLL translocations (IC50s range from 3.5 nM - 1.3 µM).
Formula:
C₃₀H₄₂N₈O₃ Peso molecolare: 562,71 g/mol Temperatura di stoccaggio: Congelamento |
MDL Number:
MFCD24849415 CAS Number: 1380288-87-8 |
Risultati del test di specificazione
Purity | ≥98% |
Formulation | A Crystalline Solid |
λmax | 255 nm |
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