Idrossiurea, crystalline powder
Fornitore: MP Biomedicals
Synonyms:
N-(Aminocarbonyl)hydroxylamine, Hydroxycarbamide
Hydroxyurea is a inhibitor of DNA synthesis in vivo, and an antiviral and antineoplastic agent which is S-phase specific.
A ribonucleotide reductase inhibitor - inhibits by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. Induces fetal hemoglobin production in sickle cell anemia patients.
It induces apoptosis of in vitro myelogenous leukemia lymphocytes, and the phosphorylation of FADD and p53. It is also used to reduce the rate of painful attacks in sickle-cell disease and has antiretroviral properties in diseases such as AIDS.
It is Anti-neoplastic. It inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronisation or cell death in S-phase.
Freely soluble in water (50 mg/ml-clear colourless solution) or hot alcohol.
Formula:
CH₄N₂O₂ Peso molecolare: 76,05 g/mol Punto di ebollizione: 296 °C (1013 hPa) Punto di fusione: 136…146 °C Temperatura di stoccaggio: Ambiente |
MDL Number:
MFCD00007943 CAS Number: 127-07-1 EINECS: 204-821-7 Merck Index: 13,04874 |
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