Stampa…

Cyclosporin A

Fornitore: ENZO LIFE SCIENCES AG

BMLA1950100 BMLA1950500
ENZOBMLA1950100EA 66 EUR
ENZOBMLA1950100 ENZOBMLA1950500
Cyclosporin A
Proteine e Peptidi

Immunosuppressant


Cyclosporin A (CsA) is an immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection. CsA binds to cyclophilin and suppresses its proline rotamase activity. The CsA-cyclophilin complex inhibits calcineurin, a type 2B phosphatase. It is an important diagnostic tool for the characterization of permeability transition-related phenomena. It inhibits mitochondrial permeability transition pore opening however, pore inhibition becomes less efficient at increasing Ca²⁺ loads and inhibition is transient. Inhibits staurosporin-induced apoptosis in cultured neural cells and rotenone-induced apoptosis in PC-12 cells. Inhibits cytochrome c release from mitochondria. Inhibits nitric oxide (NO) synthesis.


Isolated from Fusarium solani

Visualizza i codici


Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Informazioni About VWR