Tenofovir disoproxil fumarate ≥98%, crystalline solid
Fornitore: Cayman Chemical
|
Pericolo
|
Synonyms:
(R)-(((((1-(6-Amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphoryl)bis(oxy))bis(methylene) diisopropyl dicarbonate fumarate
Tenofovir disoproxil is a prodrug of the acyclic nucleoside phosphonate, tenofovir. Tenofovir is converted by cellular enzymes to tenofovir diphosphate, an obligate chain terminator that inhibits the activity of HIV reverse transcriptase and hepatitis B virus polymerase. Due to its rapid intracellular uptake, the anti-HIV activity of tenofovir disoproxil is reportedly >100-fold greater than that of the negatively charged tenofovir in a T cell line and primary blood lymphocytes.
- Crystalline solid
- Soluble in organic solvents such as ethanol, DMSO and dimethyl formamide (DMF)
- Sparingly soluble in aqueous buffers
Formula:
C₁₉H₃₀N₅O₁₀P·C₄H₄O₄ Peso molecolare: 635,5 g/mol Temperatura di stoccaggio: Congelamento |
MDL Number:
MFCD08141829 CAS Number: 202138-50-9 |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...