SKI-II ≥95%, crystalline solid
Fornitore: Cayman Chemical
Synonyms:
4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol, SKI II
Sphingosine kinase isoforms, SPHK 1 and SPHK 2, catalyse the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. Sphingosine kinase inhibitor 2 (SPHK I2) is a potent, selective inhibitor of SPHK 1 with anti-proliferative activity.
It exhibits non-ATP-competitive inhibition of human recombinant GST-SPHK 1 with an IC50 value of 0,5 µM, with no inhibition against ERK2, PI3-kinase, or PKCα at concentrations up to 60 µM. SPHK I2 inhibits proliferation of several human cancer cell lines (T-24, MCF-7, NCI/ADR, and MCF-7/VP) with IC50 values in the low µM range (0,9 to 4,6 µM).
Formula:
C₁₅H₁₁ClN₂OS Peso molecolare: 302,776 g/mol Temperatura di stoccaggio: Congelamento |
MDL Number:
MFCD00733553 CAS Number: 312636-16-1 |
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