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WYE-125132 ≥98%, crystalline solid

Fornitore: Cayman Chemical

Synonyms: 1-(4-(4-(8-Oxa-3-azabicyclo[3.2.1]octan-3-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl)phenyl)-3-methylurea, WYE-132

18372-1 18372-10 18372-5 18372-500
CAYM18372-1EA 136 EUR
CAYM18372-1 CAYM18372-10 CAYM18372-5 CAYM18372-500
WYE-125132 ≥98%, crystalline solid
WYE-125132

WYE-125132 is an ATP-competitive inhibitor of mTOR (IC50 = 0,19 nM) that inhibits signaling through both mTORC1 and mTORC2. It is selective for mTOR over phosphatidylinositol 3-kinase isoforms. WYE-125132 is effective against mTORC1 and mTORC2 in diverse cancer models, both in vitro and in vivo. Oral administration of WYE-125132 alone blocks mTOR signaling and prevents tumor growth in breast, lung, renal, and glioma cancer xenografts in mice, while combination therapy with the VEGF-inhibitor bevacizumab causes complete regression of A498 renal carcinoma tumors. In addition to its applications in cancer, WYE-125132 has been used to delineate novel aspects of mTOR signaling.

Peso molecolare: 519,6 g/mol
MDL Number: MFCD22420813
CAS Number: 1144068-46-1

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