(2'Z,3'E)-6-Bromoindirubin-3'-oxime, Millipore®
Fornitore: Merck Millipore Calbiochem
Synonyms:
GSK 3 Inhibitor IX, BIO, 6BIO, 6-Bromoindirubin-3'-oxime, (2Z,3E)-6'-Bromo-3-(hydroxyimino)-[2,3'-biindolinylidene]-2'-one
A cell-permeable bis-indolo (indirubin) compound that acts as a highly potent, selective, reversible and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM).
Inhibition of GSK by BIO has been shown to result in the activation of Wnt-signaling pathway and sustained pluripotency in human and murine ESCs (embryonic stem cells). Reported to maintain self-renewal in human and mouse embryonic stem cells.
Formula:
C₁₆H₁₀BrN₃O₂ Peso molecolare: 356,18 g/mol |
MDL Number:
MFCD08705318 CAS Number: 667463-62-9 |
Learn more
About VWR
Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...