Stampa…

Lupeol ≥98%, cristalli

Fornitore: Cayman Chemical
Attenzione

Synonyms: Fagarasterol, Monogynol B, Clerodol, 20(29)-Lupen-3β-ol, 3β-Hydroxy-20(29)-lupene

11215-5 11215-10 11215-25
CAYM11215-5EA 70.1 EUR
CAYM11215-5 CAYM11215-10 CAYM11215-25
Lupeol ≥98%, cristalli
Lupeol

Lupeol, a dietary triterpene found in certain fruits, vegetables, and medicinal plants, has potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimalarial activity. It suppresses the growth of hepatocellular carcinoma cell lines SMMC7721 and HepG2 with IC50 values of 45 and 48.5 μM and melanoma cell lines Mel 928 and Mel 1241 with IC50 values of 75 and 72 μM.¹'² At 0.76 g/kg lupeol causes a significant decrease in the blood pressure of stroke-prone hypertensive rats and reduces expression of hepatic genes involved in triglyceride and cholesterol synthesis.³ It also has significant anti-inflammatory effects at 50 mg/kg in a carrageenan-induced edema model, inhibiting neutrophil migration.⁴

1. Tarapore, R.S.,Siddiqui, I.A.,Saleem, M., et al. Specific targeting of Wnt/β-catenin signaling in human melanoma cells by a dietary triterpene lupeol. Carcinogenesis 31(10), 1844-1853 (2010).
2. He, Y.,Liu, F.,Zhang, L., et al. Growth inhibition and apoptosis induced by lupeol, a dietary triterpene, in human hepatocellular carcinoma cells. Bio.Pharm.Bull. 34(4), 517-522 (2011).
3. Ardiansyah,Yamaguchi, E.,Shirakawa, H., et al. Lupeol supplementation improves blood pressure and lipid metabolism parameters in stroke-prone spontaneously hypertensive rats. Bioscience, Biotechnology, and Biochemistry 76(1), 183-185 (2012).
4. Lucetti, D.L.,Lucetti, E.C.,Bandeira, M.A., et al. Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel. Journal of Inflammation 7(60), 1-11 (2010).

Formula: C₃₀H₅₀O
Peso molecolare: 426,7 g/mol
Temperatura di stoccaggio: Congelamento
CAS Number: 545-47-1

Visualizza i codici

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Informazioni About VWR