Stampa…

Anti-FCGR2A Mouse Monoclonal Antibody (CF594) [clone: 8.7]

Fornitore: Biotium

BNC941079-500 BNC941079-100
BNC941079-500EA 530 EUR
BNC941079-500 BNC941079-100
Anti-FCGR2A Mouse Monoclonal Antibody (CF594) [clone: 8.7]
Anticorpi
This MAb reacts with a CD32 (FcgRII) epitope distinct from that defined by MAb 8.26 and the epitope overlaps with that of MAb 7.30 (cluster 4). It displays a stronger reaction with Daudi than with U937 cells. The epitope is located in domain 2 of FcgRIIa. Its Fab'2 fragments block immune complex binding. CD32 (FcgRII) is a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.

Type: Primary
Antigen: FCGR2A
Clonality: Monoclonal
Clone: 8.7
Conjugation: CF594
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
Visualizza i codici

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Informazioni About VWR