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Anti-IVL Mouse Monoclonal Antibody (CF488A) [clone: IVRN/827]

Fornitore: Biotium
BNC880827-500 BNC880827-100
BNC880827-500EA 560 EUR
BNC880827-500 BNC880827-100
Anti-IVL Mouse Monoclonal Antibody (CF488A) [clone: IVRN/827]
Anticorpi
This antibody recognizes a protein of 66 kDa-170 kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120 kDa protein. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.

Type: Primary
Antigen: IVL
Clonality: Monoclonal
Clone: IVRN/827
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
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